456-19-9

Basic information

• Product Name: 4-FLUOROBENZAL CHLORIDE
• Synonyms: 4-FLUOROBENZAL CHLORIDE;1-(DICHLOROMETHYL)-4-FLUOROBENZENE;Benzene,1-(dichloromethyl)-4-fluoro-;4-Fluorobenzalchloride,96%;4-Fluorobenzal chloride 98%;4-Fluorobenzalchloride98%;p-Fluorbenzalchlorid;1-(Dichloromethyl)-4-fluorobenzene, 4-Fluorobenzal chloride
• CAS NO: 456-19-9
• Molecular Formula: C₇H₅Cl₂F
• Molecular Weight: 179.02
• EINECS: 207-258-5
• Mol File: 456-19-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 81-83 °C15 mm Hg(lit.)
• Flash Point: 195 °F
• Appearance: /
• Density: 1.332 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.528(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Lachrymatory
• CAS DataBase Reference: 4-FLUOROBENZAL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZAL CHLORIDE(456-19-9)
• EPA Substance Registry System: 4-FLUOROBENZAL CHLORIDE(456-19-9)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-34-36/37
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 1
• F: 19
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 456-19-9(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR LIGHT YELLOW TO GREEN LIQUID

InChI:InChI=1/C7H5Cl2F/c8-7(9)5-1-3-6(10)4-2-5/h1-4,7H

Upstream product

• 352-32-9 p-fluorotoluene 
• 14629-55-1 (4-fluorobenzyloxy)trimethylsilane 
• 18539-44-1 (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran 
• 459-56-3 4-fluorobenzylic alcohol 
• 459-57-4 4-fluorobenzaldehyde 
• 402-42-6 4-fluoro-1-trichloromethylbenzene 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 73584-06-2 diethyl α-chloro-4-fluorobenzylphosphonate 
• 1489331-54-5 bis(N,Ndiethylcarbamoyltelluro)-p-fluorophenylmethane 
• 437-23-0 ((4-fluorophenyl)methylene)dibenzene 
• 1489331-58-9 C₁₃H₁₅FTe 
• 83521-92-0 2-(4-fluorophenyl)-1,3-dimethylimidazolidine 
• 100-10-7 4-dimethylamino-benzaldehyde 

Relevant articles and documents

One-pot, oxidative and selective conversion of benzylic silyl and tetrahydropyranyl ethers to gem-dichlorides using trichloroisocyanuric acid and triphenylphosphine as an efficient and neutral system

A one-pot and oxidative method is described for the first time for the conversion of benzylic trimethylsilyl (TMS) and tetrahydropyranyl (THP) ethers to gem-dichlorides using trichloroisocyanuric acid (TCCA) and triphenylphosphine (PPh3) in neutral media. Various theses substrates containing electron withdrawing or donating groups can be efficiently converted to their corresponding gem-dichlorides in good to excellent yields. The present method shows a high degree of chemoselectivity, and due to its one-pot nature is in accordance with green chemistry.

HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS

A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection. Especially, a series of compounds that are used as NS5A inhibitors, and compositions and uses thereof in the preparations of drugs.

One-pot, selective and mild conversion of benzylic alcohols to gem -dichlorides using chlorodiphenylphosphine and 2,3-dichloro-5,6-dicyanobenzoquinone as a new and neutral system

A mild and one-pot conversion of benzylic alcohols to their corresponding gem-dichlorides is reported for the first time using chlorodiphenylphosphine (ClPPh2) and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in dichloromethane under neutral conditions and at room temperature. The present method can be efficiently used for preparation of gem-dichlorides even in the presence of some other functional groups with excellent chemoselectivity.