456-19-9

Usage

Chemical Properties

CLEAR LIGHT YELLOW TO GREEN LIQUID

InChI:InChI=1/C7H5Cl2F/c8-7(9)5-1-3-6(10)4-2-5/h1-4,7H

Upstream product

• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 352-32-9 p-fluorotoluene 
• 402-42-6 4-fluoro-1-trichloromethylbenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 
• 18539-44-1 (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran 
• 14629-55-1 (4-fluorobenzyloxy)trimethylsilane 

Downstream Products

• 26132-51-4 4-fluoro-α,α-difluorotoluene 
• 6425-24-7 1-(dibromomethyl)-4-fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 83521-92-0 2-(4-fluorophenyl)-1,3-dimethylimidazolidine 
• 73584-06-2 diethyl α-chloro-4-fluorobenzylphosphonate 
• 1489331-58-9 C₁₃H₁₅FTe 
• 437-23-0 ((4-fluorophenyl)methylene)dibenzene 
• 1489331-54-5 bis(N,Ndiethylcarbamoyltelluro)-p-fluorophenylmethane 

Relevant academic research and scientific papers

One-pot, oxidative and selective conversion of benzylic silyl and tetrahydropyranyl ethers to gem-dichlorides using trichloroisocyanuric acid and triphenylphosphine as an efficient and neutral system

A one-pot and oxidative method is described for the first time for the conversion of benzylic trimethylsilyl (TMS) and tetrahydropyranyl (THP) ethers to gem-dichlorides using trichloroisocyanuric acid (TCCA) and triphenylphosphine (PPh3) in neutral media. Various theses substrates containing electron withdrawing or donating groups can be efficiently converted to their corresponding gem-dichlorides in good to excellent yields. The present method shows a high degree of chemoselectivity, and due to its one-pot nature is in accordance with green chemistry.

Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides

Herein, a novel method for the transformation of aldehydes into geminal dichlorides based on phthaloyl chloride as reagent and N -formylpyrrolidine as Lewis base catalyst is disclosed. Given the mild reaction conditions, the current protocol is distinguished by high levels of functional group compatibility and scalability and is operationally simple. The in situ formation of a Vilsmeier Haack reagent type intermediate is likely to be essential for this organocatalytic nucleophilic substitution reaction.

HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS

A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection. Especially, a series of compounds that are used as NS5A inhibitors, and compositions and uses thereof in the preparations of drugs.

Method of manufacturing imidoyl diazidosulfochloride compd. various compd. and manufacturing method of using the same

PROBLEM TO BE SOLVED: To provide a new production method for synthesizing an imidoyl chloride compound dispensing with chlorination agents having poor handleability, to provide a method for producing various compounds in high yield and purity by using the imidoyl chloride compound, and to provide a method for isolating the imidoyl chloride compound in high efficiency and purity from a mixture of the imidoyl chloride compound and a phthalic anhydride compound.SOLUTION: The method for producing the imidoyl chloride compound comprises reaction of a specific amide compound with a specific phthaloyl chloride compound to produce a specific imidoyl chloride compound.

One-pot, selective and mild conversion of benzylic alcohols to gem -dichlorides using chlorodiphenylphosphine and 2,3-dichloro-5,6-dicyanobenzoquinone as a new and neutral system

A mild and one-pot conversion of benzylic alcohols to their corresponding gem-dichlorides is reported for the first time using chlorodiphenylphosphine (ClPPh2) and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in dichloromethane under neutral conditions and at room temperature. The present method can be efficiently used for preparation of gem-dichlorides even in the presence of some other functional groups with excellent chemoselectivity.

New preparation method for Vilsmeier reagent and related imidoyl chlorides

An environmentally benign and inexpensive preparation method is described of some imidoyl chlorides, including the Vilsmeier reagent (VR), by using phthaloyl dichloride. Synthetic applications were demonstrated using the isolated VR or VR prepared in situ for the transformation of acids to acid chlorides, alcohols to chlorides, and the formylation of dimethylaminobenzene.

A simple and efficient procedure for the preparation of benzal chlorides and benzal bromides

Benzal chlorides and benzal bromides were conveniently synthesized by reaction of aryl aldehydes with a Vilsmeier type reagent formed in situ by reduction of CCl4 or CBr4 in dimethylformamide (DMF) as solvent.

REDUKTION VON BENZOTRICHLORIDEN ZU BENZALCHLORIDEN

Benzal chlorides are prepared from the corresponding benzotrichlorides by reduction with thiophenol in the presence of catalytic amounts of copper(I) bromide.