2925-22-6

Basic information

• Product Name: DIFLUOROACETYL FLUORIDE
• Synonyms: DIFLUOROACETYL FLUORIDE
• CAS NO: 2925-22-6
• Molecular Formula: C₂HF₃O
• Molecular Weight: 98.02
• Mol File: 2925-22-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: °C
• Appearance: /
• CAS DataBase Reference: DIFLUOROACETYL FLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DIFLUOROACETYL FLUORIDE(2925-22-6)
• EPA Substance Registry System: DIFLUOROACETYL FLUORIDE(2925-22-6)

Safety Data

• Hazard Codes: C,T
• Statements: 20-34
• Safety Statements: 23-26-36/37/39-45
• RIDADR: 3308
• Hazardous Substances Data: 2925-22-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 4007, 1984 DOI: 10.1021/jo00195a025

Upstream product

• 381-73-7 Difluoroacetic acid 
• 359-11-5 1,1,2-trifluoroethylene 
• 512-51-6 Ethyl 1,1,2,2-tetrafluoroethyl ether 
• 425-88-7 1,1,2,2-tetrafluoro-1-methoxyethane 
• 79-36-7 dichloroacethyl chloride 
• 116-14-3 polytetrafluoroethylene 
• 141-78-6 ethyl acetate 
• 115611-57-9 (1,1,2,2-Tetrafluoro-ethoxymethyl)-benzene 
• 72844-39-4 Difluoro-acetic acid 2-chloro-1,1-difluoro-ethyl ester 
• 920-64-9 1-chloro-1,1,3,3-tetrafluoroacetone 
• 79-53-8 chloropentafluoroacetone 
• 79-38-9 Chlorotrifluoroethylene 
• 152239-89-9 C₃HClF₆O 
• 75-38-7 Vinylidene fluoride 

Downstream Products

• 359-13-7 difluoroethanol 
• 26132-51-4 4-fluoro-α,α-difluorotoluene 
• 55805-10-2 4-cyano-1-difluoromethylbenzene 
• 455-31-2 difluoromethylbenzene 
• 381-73-7 Difluoroacetic acid 
• 934738-22-4 1-(difluoromethyl)-4-(trifluoromethoxy)benzene 
• 1214379-64-2 C₇H₄F₄ 
• 2251-82-3 1-(difluoromethyl)-4-(trifluoromethyl)benzene 
• 444915-76-8 methyl 4-(difluoromethyl)benzoate 
• 64747-71-3 ethyl p-(difluoromethyl) benzoate 
• 64747-73-5 4-[(difluoromethyl)phenyl](phenyl)methanone 
• 176969-33-8 (E/Z)-ethyl 2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoate 
• 141573-95-7 ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 

Relevant articles and documents

Synthetic method of ethyl 4, 4-difluoro-3-oxo-2-piperidine-1-yl methylene butyrate

The invention relates to a synthetic method of ethyl 4, 4-difluoro-3-oxo-2-piperidine-1-methylene butyrate. The synthetic method comprises the following steps: 1, carrying out a condensation reactionon difluoroacetyl fluoride and 3-(1-piperidyl)-ethyl acrylate to generate 4, 4-difluoro-3-oxo-2-piperidine-1-yl methylene ethyl butyrate and hydrogen fluoride, and 2, carrying out a reaction on the hydrogen fluoride generated in the step 1 and trichloroethylene under the action of a fluorination catalyst to generate trifluoroethylene and hydrogen chloride, and 3, reacting the trifluoroethylene generated in the step 2 with oxygen under the action of a complex catalyst to generate difluoroacetyl fluoride, and recycling the difluoroacetyl fluoride generated in the step 3 as a reactant in the step1. According to the synthetic method of the ethyl 4, 4-difluoro-3oxo-2-piperidine-1-methylene butyrate, the raw materials are simple and easy to obtain, the atom utilization rate is high, and the production safety is high.

Synthetic method of difluoroacetyl fluoride

The invention relates to a synthesis method of difluoroacetyl fluoride, which comprises the following steps: 1. reacting trichloroethylene with oxygen under the catalytic action of trialkyl boron shown in the formula I to generate dichloroacetyl chloride, and 2. reacting dichloroacetyl chloride with inorganic fluoride shown in the formula II under the action of a catalyst to generate difluoroacetyl fluoride. According to the synthetic method of difluoroacetyl fluoride, the raw materials are simple and easy to obtain, high-temperature reaction is not needed, and the yield is high.

Preparation method of 2,2-difluoroacetyl fluoride and derivative thereof

The invention belongs to the field of fluorine chemical industry and particularly relates to a preparation method of 2,2-difluoroacetyl fluoride and a derivative thereof. The preparation method takes 1,1,2,2-tetrafluoroethyl ethyl ether as a raw material, and the raw material reacts under the action of a catalyst to prepare the product. The catalyst is prepared by adopting a method comprising the following steps: taking rare-earth metal oxide as a raw material and activating at high temperature; and introducing CHF2Cl and reacting. The preparation method takes the 1,1,2,2-tetrafluoroethyl ethyl ether as the raw material, and the 1,1,2,2-tetrafluoroethyl ethyl ether has oxidization reaction under the action of the catalyst at 140 DEG C to 160 DEG C to generate acyl fluoride; and the preparation method has simple and safe production steps and short reaction time.