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2925-22-6

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2925-22-6 Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 4007, 1984 DOI: 10.1021/jo00195a025

Check Digit Verification of cas no

The CAS Registry Mumber 2925-22-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,2 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2925-22:
(6*2)+(5*9)+(4*2)+(3*5)+(2*2)+(1*2)=86
86 % 10 = 6
So 2925-22-6 is a valid CAS Registry Number.

2925-22-6Relevant articles and documents

Craig et al.

, p. 3572 (1971)

Van Eijck

, p. 1,3, 5, 8-10, 12 (1977)

Decarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis

Lalloo, Naish,Malapit, Christian A.,Taimoory, S. Maryamdokht,Brigham, Conor E.,Sanford, Melanie S.

supporting information, p. 18617 - 18625 (2021/11/16)

This Article describes the development of a decarbonylative Pd-catalyzed aryl-fluoroalkyl bond-forming reaction that couples fluoroalkylcarboxylic acid-derived electrophiles [RFC(O)X] with aryl organometallics (Ar-M′). This reaction was optimized by interrogating the individual steps of the catalytic cycle (oxidative addition, carbonyl de-insertion, transmetalation, and reductive elimination) to identify a compatible pair of coupling partners and an appropriate Pd catalyst. These stoichiometric organometallic studies revealed several critical elements for reaction design. First, uncatalyzed background reactions between RFC(O)X and Ar-M′ can be avoided by using M′ = boronate ester. Second, carbonyl de-insertion and Ar-RF reductive elimination are the two slowest steps of the catalytic cycle when RF = CF3. Both steps are dramatically accelerated upon changing to RF = CHF2. Computational studies reveal that a favorable F2C-H - -X interaction contributes to accelerating carbonyl de-insertion in this system. Finally, transmetalation is slow with X = difluoroacetate but fast with X = F. Ultimately, these studies enabled the development of an (SPhos)Pd-catalyzed decarbonylative difluoromethylation of aryl neopentylglycol boronate esters with difluoroacetyl fluoride.

Synthetic method of difluoroacetyl fluoride

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Paragraph 0041; 0045-0046; 0058; 0062-0063; 0066; 0070-0071, (2020/12/10)

The invention relates to a synthesis method of difluoroacetyl fluoride, which comprises the following steps: 1. reacting trichloroethylene with oxygen under the catalytic action of trialkyl boron shown in the formula I to generate dichloroacetyl chloride, and 2. reacting dichloroacetyl chloride with inorganic fluoride shown in the formula II under the action of a catalyst to generate difluoroacetyl fluoride. According to the synthetic method of difluoroacetyl fluoride, the raw materials are simple and easy to obtain, high-temperature reaction is not needed, and the yield is high.

New process for preparing pyrazole carboxylic acid derivatives

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Paragraph 0051; 0077; 0078, (2017/04/03)

The present invention relates to a method for preparing a pyrazole carboxylic acid derivative. More particularly, the present invention relates to a novel method for preparing 1-alkyl-3-haloalkyl pyrazole-4-carboxylic acid represented by chemical formula (I) and useful for an intermediate for the preparation of a pyrazole carboxanilide-based sterilizing agent. In chemical formula (I), R_1 represents a C1-C3 lower alkyl group, R_2 represents any one of CHF_2, CF_3, CHCl_2 and CCl_2.COPYRIGHT KIPO 2017

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