26150-05-0Relevant articles and documents
Stereoselective Synthesis of Molecular Square and Granny Knots
Leigh, David A.,Pirvu, Lucian,Schaufelberger, Fredrik
, p. 6054 - 6059 (2019)
We report on the stereoselective synthesis of both molecular granny and square knots through the use of lanthanide-complexed overhand knots of specific handedness as three-crossing "entanglement synthons". The composite knots are assembled by combining two entanglement synthons (of the same chirality for a granny knot; of opposite handedness for a square knot) in three synthetic steps: first, a CuAAC reaction joins together one end of each overhand knot. Ring-closing olefin metathesis (RCM) then affords the closed-loop knot, locking the topology. This allows the lanthanide ions necessary for stabilizing the entangled conformation of the synthons to subsequently be removed. The composite knots were characterized by 1H and 13C NMR spectroscopy and mass spectrometry and the chirality of the knot stereoisomers compared by circular dichroism. The synthetic strategy of combining building blocks of defined stereochemistry (here overhand knots of λ- or Δ-handed entanglement) is reminiscent of the chiron approach of using minimalist chiral synthons in the stereoselective synthesis of molecules with multiple asymmetric centers.
Di-, Tri-, Tetra-, and Pentacationic Alkylammonium Salts. Ligands Designed To Prevent the Nonspecific Electrostatic Precipitation of Polyanionic, Functionalized Cyclopentadienyltitanium-Substituted Heteropolytungstate Electron Microscopy Labels with Cationic Biomolecules.
Keana, John F. W.,Wu, Yexin,Wu, Guanli
, p. 2571 - 2576 (1987)
This work relates to the use of organic functionalized heteropolytungstates (HPTs) as protein-specific electron microscopy labels.The objective is the development of a polycationic ligand that prevents the nonspecific precipitation reaction observed between certain polycationic biomolecules and polianionic heteropolytungstates.Simple tetra- and pentaammonium salts between Keggin HPT 1b or Dawson HPT 2b and amines 3-6 or quaternary ammonium compounds 8 and 9 were all of low aqueous solubility as were salts derived from the oxygenated partners 7, 11, 12, and 15-18.However, tetrakis quaternary salt 23a, which is made up of several highly oxygenated alkyl groups, effectively prevents precipitation between Dawson HPT 2b and the exemplary basic proteins lysozyme and poly-L-lysine as well as the lectin concanavalin A.
Synthesis of a [2]catenane around a Ru(diimine)32+ scaffold by ring-closing metathesis of olefins
Arico, Fabio,Mobian, Pierre,Kern, Jean-Marc,Sauvage, Jean-Pierre
, p. 1887 - 1890 (2003)
(Matrix presented) The synthesis of a ruthenium[2]catenane is described. One ring includes two 1,10-phenanthroline moieties, the other a bipyridinic unit. The interlocking ring system was formed by using a double ring closing metathesis reaction. Under ir
A single-mercapto double-cetyl the ether gathers glycol [...] glycolipid synthesis method (by machine translation)
-
Paragraph 0062-0065, (2019/11/04)
The invention discloses a single mercapto double-cetyl [...] glycol [...] glycolipid synthesis method, characterized in that the 2, 3, 4, 6 - O - acetyl - α - D - pyran mannose the heat stability of the polyurethane in the [...][...] benzoic acid with thr
NOVEL TRIAZINE COMPOUND, ALL-SOLID-STATE POLYMER ELECTROLYTE COMPOSITION AND USE THEREOF
-
Paragraph 0123; 0130-0132, (2018/04/12)
The present invention relates to a novel triazine compound represented by chemical formula 1, an all-solid-state polymer electrolyte composition comprising the same as a cross-linking agent and uses thereof. More specifically, the triazine compound effectively inhibits crystallization of a plasticizer at a low temperature (room temperature) to show significantly improved ion conductivity, and can realize significantly improved electrochemical stability and excellent battery properties, thereby being usefully used as an all-solid-state polymer electrolyte composition such as a lithium-polymer secondary battery, a dye-sensitized solar cell, etc.COPYRIGHT KIPO 2018
Salt- and pH-Triggered Helix-Coil Transition of Ionic Polypeptides under Physiology Conditions
Yuan, Jingsong,Zhang, Yi,Sun, Yue,Cai, Zhicheng,Yang, Lijiang,Lu, Hua
, p. 2089 - 2097 (2018/06/15)
Controlling the helix-coil transition of polypeptides under physiological conditions is an attractive way toward smart functional materials. Here, we report the synthesis of a series of tertiary amine-functionalized ethylene glycol (EGx)-linked polypeptide electrolytes with their secondary structures tunable under physiological conditions. The resultant polymers, denoted as P(EGxDMA-Glu) (x = 1, 2, and 3), show excellent aqueous solubility (>20 mg/mL) regardless of their charge states. Unlike poly-l-lysine that can form a helix only at pH above 10, P(EGxDMA-Glu) undergo a pH-dependent helix-coil switch with their transition points within the physiological range (pH ～5.3-6.5). Meanwhile, P(EGxDMA-Glu) exhibit an unusual salt-induced helical conformation presumably owing to the unique properties of EGx linkers. Together, the current work highlights the importance of fine-tuning the linker chemistry in achieving conformation-switchable polypeptides and represents a facile approach toward stimuli-responsive biopolymers for advanced biological applications.
Gold nanoparticles decorated with mannose-6-phosphate analogues
Combemale, Stephanie,Assam-Evoung, Jean-Norbert,Houaidji, Sabrina,Bibi, Rashda,Barragan-Montero, Veronique
, p. 1120 - 1149 (2014/02/14)
Herein, the preparation of neoglycoconjugates bearing mannose-6-phosphate analogues is described by: (a) synthesis of a cyclic sulfate precursor to access the carbohydrate head-group by nucleophilic displacement with an appropriate nucleophile; (b) introduction of spacers on the mannose-6-phosphate analogues via Huisgen's cycloaddition, the Julia reaction, or the thiol-ene reaction under ultrasound activation. With the resulting compounds in hand, gold nanoparticles could be functionalized with various carbohydrate derivatives (glycoconjugates) and then tested for angiogenic activity. It was observed that the length and flexibility of the spacer separating the sugar analogue from the nanoparticle have little influence on the biological response. One particular nanoparticle system substantially inhibits blood vessel growth in contrast to activation by the corresponding monomeric glycoconjugate, thereby demonstrating the importance of multivalency in angiogenic activity.
Self-assembly formation of mechanically interlocked [2]- and [3]catenanes using lanthanide ion [Eu(iii)] templation and ring closing metathesis reactions
Lincheneau, Christophe,Jean-Denis, Bernard,Gunnlaugsson, Thorfinnur
supporting information, p. 2857 - 2860 (2014/03/21)
The formation of interlocked lanthanide-based catenanes using Eu(iii)-directed synthesis is described (catenation being achieved via a ring-closing metathesis reaction); the self-assembly formation of the supramolecular structures was analysed by HRMS, NM
THIOL-ENE CLICK CHEMISTRY FOR DRUG CONJUGATES
-
Paragraph 0293; 0292, (2014/01/07)
The present invention relates to linker molecules that readily conjugate cellular recognition ligand at one end and drug payload at the other, and are useful in treating or preventing cancer, an autoimmune disease, an inflammatory condition, a central nervous system disorder or an infection. The linker inker molecules of the invention are represented by Formula I, II and III; Linker-Drug compounds represented by Formula IV, V and VI; and Ligand-Linker-Drug conjugates represented by Formula VII, VIII and IX:
Synthesis of atorvastatin lactone linker constructs for target fishing
Sawant, Pramod,Maier, Martin E.
, p. 6576 - 6585 (2013/01/15)
With the aim of connecting atorvastatin lactone 9 to a linker for affinity-based target fishing, a concise route to the pyrrolecarboxylic acid 8 was developed. Key features of the synthesis of the diol-containing side-chain were a catalytic enantioselecti
