26155-38-4

Usage

Thioamide derivative

A class of compounds PESDMA belongs to this class of compounds, which are characterized by a sulfur atom bound to an amide group.

Methylsulfanyl group

A sulfur atom bound to a methyl group This functional group is present in PESDMA, contributing to its chemical properties and reactivity.

N-(1-phenylethylideneamino) group

A nitrogen atom connected to a 1-phenylethylidene moiety This group is responsible for the compound's potential medicinal properties and reactivity in organic synthesis.

Reagent in organic synthesis

PESDMA is used as a reagent This means that it is a chemical substance that is used to carry out chemical reactions, facilitating the formation of new compounds.

Potential medicinal properties

PESDMA has been studied for its health benefits This indicates that the compound may have therapeutic uses, such as treating diseases or medical conditions.

Anti-cancer agent

PESDMA has shown potential in fighting cancer This suggests that the compound may be able to inhibit or prevent the growth of cancer cells.

Antimicrobial properties

PESDMA can combat microorganisms This means that the compound has the ability to kill or inhibit the growth of bacteria, fungi, or other microorganisms.

Antioxidant properties

PESDMA can neutralize harmful free radicals This indicates that the compound has the potential to protect cells from damage caused by oxidative stress.

Tyrosinase inhibitor

PESDMA can inhibit the enzyme tyrosinase This suggests that the compound may be able to regulate the production of melanin, which is responsible for skin pigmentation. This property could have applications in the treatment of skin conditions or cosmetic products.

InChI:InChI=1/C10H12N2S2/c1-8(11-12-10(13)14-2)9-6-4-3-5-7-9/h3-7H,1-2H3,(H,12,13)

Upstream product

• 5397-03-5 hydrazinecarbodithioic acid methyl ester 
• 98-86-2 acetophenone 
• 75-15-0 carbon disulfide 
• 74-88-4 methyl iodide 

Downstream Products

• 132856-24-7 N⁴-(2-aminophenyl)-2-(1-phenylethylidene)hydrazinecarbothioamide 
• 97483-64-2 N-(1,3-Dimethyl-imidazolidin-2-ylidene)-N'-[1-phenyl-eth-(E)-ylidene]-hydrazine 
• 97509-74-5 N-(5,5-Dimethyl-tetrahydro-pyrimidin-2-ylidene)-N'-[1-phenyl-eth-(E)-ylidene]-hydrazine 
• 97483-72-2 C₂₃H₃₀N₆S₂ 
• 84569-50-6 C₂₀H₂₂N₄S₄ 
• 129977-93-1 RuCl(CO){P(C₆H₅)3}2{C₆H₅(CH₃)CNNC(SCH₃)S} 
• 155889-17-1 {RuCl₂(P(C₆H₅)3)2((C₆H₅)(CH₃)CNNC(S)SCH₃)} 
• 93400-72-7 [Cr(CO)4(C₆H₅C(CH₃)NNHCSSCH₃)] 
• 85284-21-5 HfCl₂(C₆H₅C(CH₃)NNC(S)SCH₃)2 
• 1117816-22-4 C₂₅H₁₇ClN₄O₂S 
• 74588-14-0 (Me(Ph)CNNCSMe(S))tributyltin 
• 97483-65-3 N-(1,3-Dimethyl-tetrahydro-pyrimidin-2-ylidene)-N'-[1-phenyl-eth-(E)-ylidene]-hydrazine 
• 108901-66-2 acetophenone morpholine-N-thiohydrazone 
• 74588-13-9 (Me(Ph)CNNCSMe(S))triphenyltin 

Relevant academic research and scientific papers

Synthesis antimicrobial and anticancer activity of N′- arylmethylidene-piperazine-1-carbothiohydrazide

Ten newly synthesized thiosemicarbazones of piperazine (3a-3j) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pathogenic strains of Vibrio cholerae, protease, Candida albicans and Aspergillus niger. All the 10 compounds (3a-3j) were found to be better than Ciprofloxacin against B. subtilis and four molecules (3c, 3d, 3e, and 3h) against S. aureus. Compound 3j, a derivative of benzophenone, has been identified as a potent and promising candidate against C. albicans. The compounds were also evaluated for their anticancer activity against HBL-100 and HL60 cell lines. Compound 3a, a p-hydroxy benzaldehyde derivative, has been identified as a potent and promising candidate.

Synthesis, antimicrobial and anticancer activity of new thiosemicarbazone derivatives

Thiosemicarbazones of p-aminobenzoic acid (PABA) were synthesized and tested for their antimicrobial and anticancer activity. Hydroxamate derivatives 4a-4l were found to have better antimicrobial and anticancer activity than their acid counterpart. Compound 4d was found to have good antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Vibrio cholerae, and Bacillus subtilis with IC50 value of about 1 aμM. Compound 4f showed potent antifungal activity against Candida albicans (IC50a=a1.29 aμM) and compound 4h showed potent anticancer activity (IC50a=a0.07 aμM). Hydroxamate derivatives 4a-4l were found to show better antimicrobial and anticancer activity in compariosn with their acid counterparts 3a-3l. Copyright

Synthesis and anticancer activity of thiosemicarbazones

Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC 50 of compound III-16 against SGC-7901 reaches to 0.032 μM.

A Pummerer-Type Novel Ring Fission of 2-Methylsulfinyl-5,6-dihydro-4H-1,3,4-thiadiazine Derivatives: A Homologation of Aldehydes and Ketones

Aldehydes and ketones were converted into 2-methylsulfinyl-5,6-dihydro-4H-1,3,4-thiadiazines via the formation and base-induced ring-closure of N-alkylidene-N′-bis(alkylthio)methylenehydrazines followed by mCPBA oxidation. The subsequent Pummerer-type ring fission of the rings was performed by treating with trifluoroacetic anhydride or trifluoromethanesulfonic anhydride at -78°C to give α,β-unsaturated esters and ketones in modest yields. Thus, this reaction sequence was regarded as being a new method for the two-carbon homologation of aldehydes and ketones.

A Homologation of Aldehydes and Ketones via the Formation and the Subsequent Pummerer-type Ring Fission of 2-Methylsulfinyl-5,6-dihydro-4H-1,3,4-thiadiazine Derivatives

A two-carbon homologation of aldehydes and ketones was achieved by using a sequence involving the formation and the subsequent Pummerer-type ring fission of 5,6-dihydro-4H-1,3,4-thiadiazine rings possessing methylsulfinyl functionality at C-2.

A Facile Synthesis of Unsymmetrical Heterocyclic Azines by Cyclodesulfurization: Reaction of Methyl Arylalkylidenehydrazinecarbodithioates with Diamines

A new and facile synthesis of unsymmetrical heterocyclic azines is described.Methyl arylalkylidenehydrazinecarbodithioates, prepared by the condensation of ketones or aldehydes with methyl hydrazinecarbodithioate, were heated under reflux with various dia