261956-65-4

Basic information

• Product Name: 2-chloro-5-(trifluoromethyl)pyridine 1-oxide
• Synonyms: 2-chloro-5-(trifluoromethyl)pyridine 1-oxide
• CAS NO: 261956-65-4
• Molecular Formula: C₆H₃ClF₃NO
• Molecular Weight: 197.5423296
• Mol File: 261956-65-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-5-(trifluoromethyl)pyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-(trifluoromethyl)pyridine 1-oxide(261956-65-4)
• EPA Substance Registry System: 2-chloro-5-(trifluoromethyl)pyridine 1-oxide(261956-65-4)

Safety Data

• Hazardous Substances Data: 261956-65-4(Hazardous Substances Data)

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 1076234-45-1 3,4-dimethyl-1-{[6-phenyl-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione 
• 1076234-34-8 1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-di-methylazoline-2,5-dione 
• 55304-75-1 2,6-dichloro-3-(trifluoromethyl)pyridine 

Relevant articles and documents

SUBSTITUTED AZOLE DIONE COMPOUNDS WITH ANTIVIRAL ACTIVITY

Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.

Fluorescence polarization for the evaluation of small-molecule inhibitors of PCAF BRD/Tat-AcK50 association

A fluorescence polarization competitive assay was developed to efficiently screen and evaluate inhibitors of PCAF bromodomain/Tat-AcK50 protein-peptide interaction. A series of pyridine 1-oxide derivatives were synthesized and evaluated. Some of the novel

Compounds with anti-cancer activity

Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.