2621-67-2

Upstream product

• 67-56-1 methanol 
• 2612-57-9 2,4-dichlorophenyl isocyanate 
• 2447-79-2 2,4-dichlorobenzamide 
• 619-56-7 4-chlorobenzamide 
• 56843-28-8 2,4-dichlorobenzaldoxime 

Relevant academic research and scientific papers

Palladium-Catalyzed Carbamate-Directed Regioselective Halogenation: A Route to Halogenated Anilines

This study describes an efficient method for ortho-selective halogenation of N-arylcarbamates under mild conditions for the first time. Although being weakly coordinating, N-arylcarbamates act very well as a removable directing group for activation of C-H bonds. The developed procedure results in extremely valuable halogenated N-arylcarbmates that can further be hydrolyzed to halogenated anilines. The obtained reaction conditions showed broad scope and wide functional group tolerance. All the products were formed in good yields with extremely high selectivity.

(Tosylimino)phenyl-λ3-iodane as a reagent for the synthesis of methyl carbamates via hofmann rearrangement of aromatic and aliphatic carboxamides

A new, mild procedure for the Hofmann rearrangement of aromatic and aliphatic carboxamides using (tosylimino)phenyl-λ3-iodane, PhINTs, as a reagent is reported. Because of the mild reaction conditions, this method is particularly useful for the Hofmann rearrangement of substituted benzamides, which usually afford complex reaction mixtures with other hypervalent iodine oxidants. The mild reaction conditions and high selectivity in the reaction of carboxamides with PhINTs allow the isolation of the initially formed labile isocyanates or their subsequent conversion to stable carbamates by treatment with alcohols.

Methyltrioxorhenium-catalyzed oxidation of aromatic aldoximes

The first catalytic oxidation of aryl oximes to nitro compounds by means of methyltrioxorhenium and urea hydroperoxide is reported. The formation of carbamates, probably occurring through formation of nitrile oxide intermediates, has been observed from 2,6-disubstituted aryl oximes.