26210-43-5Relevant academic research and scientific papers
Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy
Mallikarjun Reddy,Moses Babu,Sudhakar,Sharma,Sudershan Reddy,Vyas
, p. 994 - 998 (2007/10/03)
Three unknown impurities in racecadotril bulk drug at levels below 0.5% were detected by simple reverse phase isocratic high performance liquid chromatography (HPLC). Structures for these impurities were proposed by molecular ion information and their fragmentation pattern obtained by LC-MS and these impurities were confirmed by NMR spectroscopy. The impurities I, II and III were characterized as benzyl 2-methyl carboximido acetate, benzyl 2-phenyl ethyl carboximido acetate, and benzyl 2-(1-benzyl vinyl carboximido) acetate. These structures were further confirmed by co-injecting of synthetic standards of impurities with racecadotril. The mechanism of the formation of these process related impurities is discussed.
PREPARATION OF ESTERS OF AMINO ACIDS AND OF PEPTIDES UNDER MILD CONDITION
Mazurov, A. A.,Antonenko, S. V.,Andronati, S. A.
, p. 208 - 210 (2007/10/02)
A new method of obtaining esters of N-protected amino acids and peptides from complexes of their sodium salts with 15-crown-5 that are soluble in organic solvents is proposed.
