7386-66-5Relevant academic research and scientific papers
One-Pot Synthesis of β,β-Disubstituted α,β-Unsaturated Carbonyl Compounds
Sugiura, Masaharu,Ashikari, Yasuhiko,Nakajima, Makoto
, p. 8830 - 8835 (2015/09/15)
TiCl4-promoted aldol reaction of ketones as aldol acceptors followed by elimination of the titanoxy group from the Ti-aldolates affords β,β-disubstituted α,β-unsaturated carbonyl compounds in a one-pot procedure. The use of additives, such as DMF, N,N,N′,N′-tetramethylethylenediamine, and pyridine, in the elimination step was found to be important.
Enantioselective Conjugate Reduction of α,β-Unsaturated Carboxamides with Semicorrin Cobalt Catalysts
Matt, Peter von,Pfaltz, Andreas
, p. 691 - 700 (2007/10/02)
Chiral semicorrin cobalt complexes, prepared in situ from cobalt(II) chloride and the free ligands, are efficient, highly enantioselective catalysts for the conjugate reduction of α,β-unsaturated carboxamides with sodium borohydride.Enantiomeric excesses of up to 99percent, essentially quantitative yields, and high substrate/catalyst ratios (1000-10 000:1) are attractive attributes of this catalytic process.
