26226-58-4

Usage

Uses

Used in Organic Synthesis:
(2E)-2-(hydroxyimino)-1-phenylpropan-1-ol is used as a reagent in organic synthesis for its ability to undergo various chemical transformations, contributing to the formation of complex organic molecules.
Used in Pharmaceutical Preparation:
(2E)-2-(hydroxyimino)-1-phenylpropan-1-ol is used as a key intermediate in the preparation of pharmaceuticals, playing a crucial role in the development of new drugs.
Used in Agrochemicals:
(2E)-2-(hydroxyimino)-1-phenylpropan-1-ol is used in the preparation of agrochemicals, contributing to the development of effective and safe products for agricultural applications.
Used in Medicinal Chemistry and Drug Development:
(2E)-2-(hydroxyimino)-1-phenylpropan-1-ol is used as a compound with potential applications in medicinal chemistry and drug development, offering opportunities for the discovery of new therapeutic agents.

Upstream product

• 90-63-1 (RS)-1-hydroxy-1-phenylpropan-2-one 
• 119-51-7 1-phenyl-1,2-propanedione 2-oxime 
• 145614-27-3 1-phenyl-1-<1-phenyl-5(1H)-tetrazolylthio>propan-2-one oxime 
• 22596-45-8 trans-2-methyl-2-nitro-3-phenyloxirane 
• 4410-31-5 (RS)-mandelamide 

Downstream Products

• 54680-46-5 norephedrine 
• 14838-15-4 u-2-amino-1-phenylpropan-1-ol 
• 100-52-7 benzaldehyde 
• 90-63-1 (RS)-1-hydroxy-1-phenylpropan-2-one 

Relevant academic research and scientific papers

Kinetics and Mechanism of the Alkaline Release of Phenyl(mercapto)tetrazoles from α-Oximes

Compounds such as α-phenyl(mercapto)tetrazole (PMT) oxime (9) undergo rapid elimination of the PMT anion in base via a nitrosoene intermediate.Solution kinetics and HPLC analysis of reaction products are consistent with the mechanism shown in Scheme 2.For open chain oximes such as 4, substitution α to the oxime increases the rate of release of PMT and is attributed to the relief of strain when a crowded reactant is converted to a less-crowded product.For cyclic oximes, the six-membered ring compounds are more reactive than the corresponding five-membered compounds.A linear isokinetic relationship between the entropy and enthalpy of activation was found with β = 346 +/- 51 K.Entropies of activation were found to range from -7 to +24 c.u. (1 c.u. = 4.184 J mol-1 K-1) and support the proposed mechanism.

The chlorination of propiophenone; determination of pKa value and the course of the reaction

Chlorination of propiophenone in alkaline aqueous solution lead to formation of α-hydroxypropiophenone as the first detectable intermediate; this undergoes slower oxidation to aromatic acids without any accumulation of further intermediates.From the rates of the initial chlorination we have been able to determine the pKa value as 17.56 +/- 0.51.Key words: propiophenone, chlorination, hydrolysis, rearrangement, pKa.