2623-45-2

Basic information

• Product Name: Ethanone, 2-chloro-1-(2,4-dimethylphenyl)- (9CI)
• Synonyms: Ethanone, 2-chloro-1-(2,4-dimethylphenyl)- (9CI);α-Chloro-2',4'-dimethylacetophenone;ω-Chloro-2',4'-dimethylacetophenone;2-chloro-1-(2,4-dimethylphenyl)ethan-1-one
• CAS NO: 2623-45-2
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.64674
• Product Categories: ACETYLHALIDE
• Mol File: 2623-45-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 62-63 °C
• Boiling Point: 276°Cat760mmHg
• Flash Point: 141.7°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0.00492mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: Ethanone, 2-chloro-1-(2,4-dimethylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-(2,4-dimethylphenyl)- (9CI)(2623-45-2)
• EPA Substance Registry System: Ethanone, 2-chloro-1-(2,4-dimethylphenyl)- (9CI)(2623-45-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 2623-45-2(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-chloro-1-(2,4-dimethylphenyl)- (9CI) is a chemical compound with the molecular formula C10H11ClO. It is also known by its chemical name 2-Chloro-1-(2,4-dimethylphenyl)ethanone. Ethanone, 2-chloro-1-(2,4-dimethylphenyl)- (9CI) is a chlorinated ketone with a substituted phenyl group. It is commonly used in organic synthesis and pharmaceutical research as an intermediate in the production of pharmaceuticals and fine chemicals. It is also used in the manufacturing of agrochemicals and other specialty chemicals. The compound is known for its ability to react with a variety of reagents, making it a versatile building block in organic synthesis. However, it is important to handle this chemical with care as it is flammable and may cause irritation to the skin, eyes, and respiratory system if not handled properly.

InChI:InChI=1/C10H11ClO/c1-7-3-4-9(8(2)5-7)10(12)6-11/h3-5H,6H2,1-2H3

Upstream product

• 854861-66-8 1-iodoethynyl-2,4-dimethyl-benzene 
• 79-11-8 chloroacetic acid 
• 108-38-3 m-xylene 
• 64-17-5 ethanol 
• 105738-24-7 7-chloroacetyloxy-4-methylcoumarin 
• 182115-37-3 2-oxo-2H-chromen-7-yl chloroethanoate 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 109646-60-8 1-(2,4-dimethyl-phenacyl)-3-hydroxy-pyridinium; chloride 
• 65782-61-8 2-(benzo[d]thiazol-2-ylthio)-1-(2,4-dimethylphenyl)ethanone 
• 554-68-7 triethylamine hydrochloride 
• 120027-77-2 3-[2-(2,4-Dimethyl-phenyl)-2-oxo-ethyl]-3H-benzooxazol-2-one 
• 120007-61-6 2-(Benzooxazol-2-ylsulfanyl)-1-(2,4-dimethyl-phenyl)-ethanone 
• 91061-51-7 (rac)-2-(2,4-dimethylphenyl)-2-hydroxyacetic acid 
• 842136-27-0 5-bromo-2,4-dimethylbenzoic acid 
• 611-01-8 2,4-dimethyl-benzoic acid 

Relevant articles and documents

Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin

A series of α-triazolyl chalcones were efficiently synthesized. Most of the prepared compounds showed effective antibacterial and antifungal activities. Noticeably, α-triazolyl derivative 9a exhibited low MIC value of 4 μg/mL against MRSA and Micrococcus luteus, which was comparable or even superior to reference drugs. The further research revealed that compound 9a could effectively intercalate into Calf Thymus DNA to form 9a-DNA complex which might block DNA replication to exert their powerful antimicrobial activities. Competitive interactions between 9a and metal ions to Human Serum Albumin (HSA) suggested the participation of Fe3+, K+ and Mg 2+ ions in 9a-HSA system could increase the concentration of free 9a, shorten its storage time and half-life in the blood, thus improving its antimicrobial efficacy.

Simple and efficient procedure for the friedel-crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/AL2O3 under heterogeneous conditions

An efficient and chemoselective method for the Friedel-Crafts acylation of aromatic compounds using P2O5/Al2O3 and carboxylic acids. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones in good yields.

Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 under heterogeneous conditions

A convenient and efficient procedure for the Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 is described. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.