842136-27-0

Basic information

• Product Name: 5-bromo-2,4-dimethylbenzoic acid
• Synonyms: 5-bromo-2,4-dimethylbenzoic acid
• CAS NO: 842136-27-0
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07056
• Mol File: 842136-27-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-bromo-2,4-dimethylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2,4-dimethylbenzoic acid(842136-27-0)
• EPA Substance Registry System: 5-bromo-2,4-dimethylbenzoic acid(842136-27-0)

Safety Data

• Hazardous Substances Data: 842136-27-0(Hazardous Substances Data)

Usage

General Description

5-bromo-2,4-dimethylbenzoic acid is a chemical compound with the molecular formula C9H9BrO2. It is classified as a benzoic acid derivative and contains a bromine atom and two methyl groups attached to a benzoic acid ring. 5-bromo-2,4-dimethylbenzoic acid is commonly used as a building block in organic synthesis and pharmaceutical research. It has potential applications in the development of various pharmaceuticals and agrochemicals. Additionally, 5-bromo-2,4-dimethylbenzoic acid may also be used as a reagent in chemical reactions and as a reference standard for analytical assays. Its unique structural characteristics make it a valuable and versatile compound in the field of organic chemistry.

Upstream product

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Relevant articles and documents

2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-4-METHYLBENZAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS RIPK2 INHIBITORS FOR TREATING E.G. AUTOIMMUNE DISEASES

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein α, β, R2, R3, R4, R5, R8, R9, X1, X6, and X7 are defined in the specification. The compounds of formula 1 are receptor-interacting protein kinase 2 (RIPK2) inhibitors for treating e.g. type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer and non-malignant proliferative disorders, such as e.g. allergic rhinitis, asthma, atopic dermatitis, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, lupus nephritis, psoriasis, immune thrombocytopenic purpura, inflammatory bowel disease, chronic obstructive pulmonary disease, Sjogren's syndrome, ankylosing spondylitis, Behcet's disease, graft versus host disease, pemphigus vulgaris, idiopathic plasmacytic lymphadenopathy, atherosclerosis, myocardial infarction and thrombosis. The present description discloses the preparation of exemplary compounds as well as pharmacological data thereof (e.g. pages 107 to 208; examples 1 to 109; table 1). An exemplary compound is e.g. N-cyclopropyl-2-fluoro-5-(l-(2-fluoroethyl)-3-(l-hydroxy-2-methylpropan-2-yl)-2-oxo-2,3-dihydro-lH-imidazo[4,5-b]pyridin-6-yl)-4-methylbenzamide (example 1).

Palladium-Catalyzed ortho-C-H Methylation of Benzoic Acids

A palladium-catalyzed methylation of C-H bonds of benzoic acids with di-tert-butyl peroxide as the methylating reagent under an external oxidant and ligand-free conditions has been achieved. The reaction is found to be directed by a weakly coordinating carboxyl group, offering a facile route for the synthesis of highly functionalized ortho-methyl benzoic acids.

PHENYL mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.