2625-60-7

Basic information

• Product Name: 17-acetyl-10,13-dimethyl-1,2,6,7,8,9,14,15,16,17-decahydrocyclopenta[a ]phenanthren-3-one
• Synonyms: 17-acetyl-10,13-dimethyl-1,2,6,7,8,9,14,15,16,17-decahydrocyclopenta[a ]phenanthren-3-one
• CAS NO: 2625-60-7
• Molecular Formula: C21H28O2
• Molecular Weight: 312.45
• Mol File: 2625-60-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 451.5 °C at 760 mmHg
• Flash Point: 168.2 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 2.43E-08mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 17-acetyl-10,13-dimethyl-1,2,6,7,8,9,14,15,16,17-decahydrocyclopenta[a ]phenanthren-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 17-acetyl-10,13-dimethyl-1,2,6,7,8,9,14,15,16,17-decahydrocyclopenta[a ]phenanthren-3-one(2625-60-7)
• EPA Substance Registry System: 17-acetyl-10,13-dimethyl-1,2,6,7,8,9,14,15,16,17-decahydrocyclopenta[a ]phenanthren-3-one(2625-60-7)

Safety Data

• Hazardous Substances Data: 2625-60-7(Hazardous Substances Data)

Usage

General Description

17-acetyl-10,13-dimethyl-1,2,6,7,8,9,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one is a chemical compound belonging to the class of cyclopenta[a]phenanthrenes. It is a steroid derivative with a molecular formula of C21H28O2 and a molecular weight of 312.44 g/mol. 17-acetyl-10,13-dimethyl-1,2,6,7,8,9,14,15,16,17-decahydrocyclopenta[a ]phenanthren-3-one is commonly found as a natural product in some plant species and fungi. It is also used in pharmaceutical research and development due to its potential therapeutic properties. Its chemical structure and properties make it an important molecule for the study of steroid chemistry and its biological effects.

InChI:InChI=1/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h9,11-12,16-19H,4-8,10H2,1-3H3

Upstream product

• 108-75-8 2,4,6-trimethyl-pyridine 
• 115758-63-9 12α-(toluene-4-sulfonyloxy)-pregn-4-ene-3,20-dione 
• 96671-93-1 4β,11β,12α-Tribrom-5β-pregnandion-(3,20) 
• 106168-72-3 3-Ethylendioxy-5β-pregnen-(11)-on-(20) 
• 95949-16-9 11β,12α-Dibrom-5β-pregnandion-(3,20) 
• 98-59-9 p-toluenesulfonyl chloride 
• 80-75-1 11-alpha-hydroxyprogesterone 
• 1109-03-1 12α-(toluene-sulfonyl-(4)-oxy)-5β-pregnanedione-(3,20) 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 10116-24-2 11α-methanesulfonyloxy-pregn-4-ene-3,20-dione 
• 96214-00-5 11β,12α-Dibrom-pregnen-(4)-dion-(3,20) 
• 115759-02-9 11α-hydroxyprogesterone toluene-p-sulphonate 
• 83603-62-7 12α-acetoxy-pregn-4-ene-3,20-dione 

Downstream Products

• 1099-20-3 11β,12β-Epoxy-pregn-4-en-3,20-dion 
• 1242-47-3 12α-bromo-11β-hydroxy-pregn-4-ene-3,20-dione 

Relevant articles and documents

STEROIDS AND RELATED PRODUCTS. XVIII. THE SYNTHESIS OF 11-BETA,

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Chloromethanesulfonate as an efficient leaving group: Rearrangement of the carbon-carbon bond and conversion of alcohols into azides and nitriles

The chloromethanesulfonate (monochlate) served as an efficient leaving group for rearrangement of the carbon-carbon bond and conversion of alcohols into azides and nitriles. The treatment of the monochlate 16a with zinc acetate in dioxane at 90 °C effected migration of the 4α-methyl group to give alkene 17a. Upon similar treatment of the monochlates 22a, 25a, 28a, and 31a with zinc acetate, the carbon-carbon bonds antiperiplanar to the hydroxyl groups efficiently migrated to afford the alkenes 23a, 26a-c, 29a,b, and 32a, respectively. In the case of the diol 40, the monochlate was converted into the ketone 41 via a rearrangement-ring expansion. The reaction of the monochlates 44a, 47a, 49a, 52a, and 57a with sodium azide or lithium azide in N,N-dimethylformamide efficiently afforded the azides with inversion of the configuration. The introduction of a nitrile group to the sterically hindered alcohol 59 was performed in high yield by the reaction of the monochlate 60a with sodium cyanide.

C(10) methylation of steroidal synthesis intermediate BCD tricyclic 9 en 5 ones

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