263887-30-5

Upstream product

• 50-00-0 formaldehyd 
• 21541-60-6 3-phenylprop-2-ynyl 4-methylbenzenesulfonate 
• 420121-38-6 methyl (3-phenylprop-2-yn-1-yl) carbonate 
• 5661-50-7 N-(phenoxy)acetamide 
• 1839-72-1 2-phenylbenzofuran 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 100-39-0 benzyl bromide 
• 90-02-8 salicylaldehyde 
• 64908-64-1 2-phenoxyisoindol-1,3-dione 
• 98-80-6 phenylboronic acid 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 4846-21-3 O-phenylhydroxylamine 
• 536-74-3 phenylacetylene 
• 870011-27-1 tert-butyl-dimethyl-(2-phenylethynyl-phenoxymethoxy)-silane 

Downstream Products

• 1447799-60-1 1-((2-phenylbenzofuran-3-yl)methyl)-1H-benzo[d]imidazole 
• 1447799-58-7 1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazole 
• 1447799-97-4 4-butyl-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-96-3 4-(2-bromobenzyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-95-2 4-benzyl-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-94-1 4-(2-oxo-1,2-diphenylethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-93-0 4-(2-(naphthalen-2-yl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-92-9 4-(2-(4-bromophenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-91-8 4-(2-(4-fluorophenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-90-7 4-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-89-4 4-(2-(4-hydroxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-88-3 4-(2-oxo-2-phenylethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole-4-ium bromide 
• 1447799-87-2 1-((2-phenylbenzofuran-3-yl)methyl)-1H-1,2,4-triazole 
• 1447799-86-1 3-(2-bromobenzyl)-2-ethyl-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide 

Relevant academic research and scientific papers

Cascade Synthesis of 3-Alkylidene Dihydrobenzofuran Derivatives via Rhodium(III)-Catalyzed Redox-Neutral C-H Functionalization/Cyclization

An efficient rhodium(III)-catalyzed coupling reaction of N-phenoxyacetamides with propargyl carbonates to yield 3-alkylidene dihydrobenzofuran derivatives via C-H functionalization/cascade cyclization has been developed. This transformation represents a r

Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3- alkylbenzofuran and imidazole/triazole compounds

A series of novel hybrid compounds of 2-phenyl-3-alkylbenzofuran and imidazole or triazole were prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the 2-ethyl-imidazole ring, and substitution of the imidazo

Rhodium(III)-catalyzed redox-neutral coupling of N-phenoxyacetamides and alkynes with tunable selectivity

Give it a tweak: A novel oxidizing directing group was developed for a rhodium(III)-catalyzed C-H functionalization of N-phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho-hydroxyphenyl-substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp=C5Me5). Copyright

Synthesis of 2,3-disubstituted benzofurans and indoles by π-Lewis acidic transition metal-catalyzed cyclization of ortho-alkynylphenyl O,O- and N,O-acetals

The PtCl2-catalyzed cyclization reaction of ortho-alkynylphenyl acetals 1 in the presence of COD (1,5-cyclooctadiene) produces 3-(α-alkoxyalkyl)benzofurans 2 in good to high yields. For example, the reaction of acetaldehyde ethyl 2-(1-octynyl)phenyl acetal (1a), acetaldehyde ethyl 2-(cyclohexylethynyl)phenyl acetal (1c), and acetaldehyde ethyl 2-(phenylethynyl)phenyl acetal (1f) in the presence of 2 mol % of platinum(II) chloride and 8 mol % of 1,5-cycloocatadiene in toluene at 30 °C gave the corresponding 2,3-disubstituted benzofurans 2a, 2c, and 2f in 91, 94, and 88% yields, respectively. Moreover, the reaction of N-methoxymethyl-2-alkynylanilines 3 was catalyzed by PdBr2, affording the corresponding 2,3-disubstituted indoles 4 in moderate yields. For example, the reaction of N-methoxymethyl-2-(1-pentynyl)-N-tosylaniline (3a) and N-methoxymethyl-2-(phenylethynyl)-N-tosylaniline (3b) in the presence of 10 mol % of PdBr2 in toluene at 80 °C gave 3-methoxymethyl-2-propyl-1-tosylindole (4a) and 3-methoxymethyl-2-phenyl-1-tosylindole (4b) in 33 and 33% yields, respectively.

Synthesis of 2,3-disubstituted benzofurans by platinum olefin-catalyzed carboalkoxylation of o-alkynylphenyl acetals

The PtCl2-catalyzed cyclization reaction of o-alkynylphenyl acetals 1 in the presence of 1,5-cyclooctadiene produces 3-(α-alkoxyalkyl)benzofurans 2 in good to high yields. For example, the reaction of acetaldehyde ethyl 2-(1-octynyl)phenyl acetal (1a), acetaldehyde ethyl 2-(cyclohexylethynyl)phenyl acetal (1c), and acetaldehyde ethyl 2-(phenylethynyl)phenyl acetal (1f) in the presence of 2 mol % of platinum(II) chloride and 8 mol % of 1,5-cyclooctadiene in toluene at 30 °C gave the corresponding 2,3-disubstituted benzofurans 2a, 2c, and 2f in 91, 94, and 88% yields, respectively. Copyright

An expeditious synthesis of vibsanol, a benzofuran-type lignan from Viburnum awabuki

Vibsanol (1), a benzofuran-type lignan isolated from the wood of Viburnum awabuki (Caprifoliaceae), was synthesized from the readily available vanillin; the key step is a tandem cyclization of o-tert- butyldimethylsiloxydiarylalkyne (2) with tetrabutylammonium fluoride and excess paraformaldehyde.

Total synthesis of vibsanol, a benzofuran-type lignan

Vibsanol (1), a benzofuran-type lignan isolated from the wood of Viburnum awabuki (Caprifoliaceae), was synthesized by the tandem cyclization of o-tert-butyldimethylsiloxydiarylalkyne with tetrabutylammonium fluoride and excess paraformaldehyde as the key step.