26429-41-4

Usage

Uses

Used in Organic Synthesis:
1,2-Dibromo-3-nitrobenzene is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its reactivity allows it to undergo multiple types of chemical reactions, making it a versatile building block in the synthesis of complex organic molecules.
Used in Dye Production:
In the dye industry, 1,2-Dibromo-3-nitrobenzene is used as an intermediate in the production of dyes. Its chemical properties enable the creation of dyes with specific color characteristics and properties, contributing to the development of a wide range of dyes for various applications.
Used in Pharmaceutical Industry:
1,2-Dibromo-3-nitrobenzene is utilized as an intermediate in the synthesis of pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs with specific therapeutic properties.
Used in Research and Development:
In the field of research and development, 1,2-Dibromo-3-nitrobenzene serves as a model compound for studying various chemical reactions and exploring new synthetic pathways. Its reactivity and structural features provide insights into the mechanisms of electrophilic and nucleophilic aromatic substitutions, contributing to the advancement of organic chemistry.

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 602-03-9 2,3-dinitroaniline 
• 583-53-9 2,3-dibromobenzene 
• 7697-37-2 nitric acid 
• 10035-10-6 hydrogen bromide 
• 64-19-7 acetic acid 
• 615-36-1 2-bromoaniline 
• 88-74-4 2-nitro-aniline 
• 59255-95-7 2-bromo-6-nitroaniline 

Downstream Products

• 619-03-4 3,4-dibromobenzoic acid 
• 96558-80-4 1,2-dibromo-3,5-dinitrobenzene 
• 59255-95-7 2-bromo-6-nitroaniline 
• 608-22-0 3-amino-1,2-dibromobenzene 
• 3970-37-4 1-bromo-2-chloro-3-nitrobenzene 
• 121866-22-6 2-heptylphenylamine 
• 121866-23-7 o-n-heptylacetanilide 
• 615-55-4 3,4-dibromoaniline 
• 90481-68-8 1-bromo-2-ethenyl-3-nitrobenzene 
• 1201561-34-3 4-phenyl-9H-carbazole 
• 32337-96-5 1-bromo-2-iodo-3-nitro-benzene 

Relevant academic research and scientific papers

PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE

The present invention discloses substituted pyrimidine and pyrimido indole compounds and optionally pharmaceutically acceptable salts, hydrates or solvates thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt, hydrate, or solvate thereof.

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists based on a 4-piperazinylbenzimidazole template, we sought to investigate the properties of heterocyclic isosteres of the benzimidazole template. We report here the synthesis and biological activity of eight novel scaffolds, including imidazopyridines, benzothiazoles and benzoxazoles. The 2-(4-tert-butylphenyl)-8-(piperazin-1-yl)imidazo[1,2-a]pyridine ring system was shown to have nanomolar binding potency at the human and rat GnRH receptors as well as functional antagonism in vitro. Additional structure-activity relationships within this series are reported along with a pharmacokinetic comparison to the benzimidazole-based lead molecule.

Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor

The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.

An application of the stille coupling for the preparation of arylated phthalonitriles and phthalocyanines

The substituted phthalonitriles 4-phenylphthalonitrile (2a), 4-(2,5-dimethoxyphenyl)phthalonitrile (2b) and 2-(3,4-dicyanophenyl)-4-methylpyridine (2c) have been prepared in good yields from 4-iodophthalonitrile 3, the synthesis of which is also discussed, using the Stille coupling method. Such phthalonitriles are precursors for phthalocyanines with the possibility of biphenyl-like orientation of a peripheral substituent with respect to the macrocycle ring plane. As an example, 2b was used in the preparation of tetra(dimethoxyphenyl)phthalocyanine 1a. Both 1a and the corresponding zinc(II) complex show good solubility in non-polar solvents such as dichloromethane.

Synthesis of Mercapturic Acid Derivatives of Putative Toxic Metabolites of Bromobenzene

The synthesis and characterization of nine isomerically defined S-arylmercapturic acids of interest in connection with the metabolism of the model hepatotoxin bromobenzene is described.Included are three S-(bromophenyl)-, two S-(bromohydroxyphenyl)-, and three S-(bromodihydroxyphenyl)mercapturic acids of defined substitution pattern.In addition, several related compounds with two or no bromine atoms are described.These syntheses depend on two basic methods, 1,4-addition of various arene thiols to acetamidoacrylic acid or the 1,4-addition of N-acetyl-L-cysteine to various benzoquinone derivatives.In addition, we describe a method for efficient conversion of the mercapturic acids to thioanisole derivatives, regioisomers of which can be separed and detected at low levels by capillary gas-liquid chromatography.