26478-92-2Relevant academic research and scientific papers
Consecutive Alkynylation-Michael Addition-Cyclocondensation (AMAC) Multicomponent Syntheses of α-Pyrones and α-Pyridones
Breuer, Natascha,Müller, Thomas J. J.
, p. 2741 - 2752 (2018/06/08)
A novel consecutive three-component synthesis of α-pyrones is based upon an alkynylation-Michael addition-cyclocondensation (AMAC) sequence, starting from (hetero)aroyl chloride and terminal alkyne to furnish the alkynone which reacts with malonates to gi
2-pyridone synthesis using 2-(phenylsulfinyl)acetamide
Fujii, Masaya,Nishimura, Takuya,Koshiba, Takahiro,Yokoshima, Satoshi,Fukuyama, Tohru
supporting information, p. 232 - 234 (2013/04/10)
2-Pyridones were prepared by means of an efficient protocol including the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination.
A regioselective tandem reaction between chalcones and 2-acetamido-acetamide promoted by Cs2CO3 for the preparation of 3-unsubstituted 2-pyridones
Wang, Shaozhong,Yu, Gang,Lu, Jun,Xiao, Kun,Hu, Yuefei,Hu, Hongwen
, p. 487 - 490 (2007/10/03)
A novel procedure was developed for the preparation of 3-unsubstituted 2-pyridones by a tandem reaction between chalcones and 2-acetamidoacetamide. The regioselectivity was affected mainly by base used in the reaction. For the symmetrical chalcones, satisfactory results were obtained when the reaction was catalyzed by sodium hydroxide. In the case of unsymmetrical chalcones, cesium carbonate was used as a base to yield desired products regioselectively.
SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS
-
, (2008/06/13)
This invention relates to compounds having selective LTB 4 antagonist properties, compositions comprising said compounds and methods for the treatment of disorders involving LTB 4 agonist-mediated activity utilizing said compositions wherein the compounds
ω-alkanoic Acid Derivatives: A New Family of Potent and Orally Active LTB4 Antagonists
Labaudiniere, Richard,Dereu, Norbert,Cavy, Francois,Guillet, Marie-Christine,Marquis, Olivier,Terlain, Bernard
, p. 4315 - 4324 (2007/10/02)
A series of ω-alkanoic acid derivatives was prepared which inhibited the binding of leukotriene B4 to its receptors on guinea pig spleen membranes and on human polymorphonuclear leukocytes (PMNs) and selectively ant
