265989-32-0 Usage
Uses
Used in Pharmaceutical Industry:
N-4-Phenyl a-Benzylidene-d5 Isobutyrylacetamide is used as an intermediate in the synthesis of Atorvastatin for the treatment of hypercholesterolemia. It helps in lowering elevated LDL-cholesterol and triglyceride levels in patients, thus reducing the risk of cardiovascular diseases.
Used in Research and Development:
N-4-Phenyl a-Benzylidene-d5 Isobutyrylacetamide is also used as a research compound in the development of new drugs and therapies targeting hypercholesterolemia and related cardiovascular conditions. Its deuterated nature allows for the study of its properties and potential applications in drug design and development.
Check Digit Verification of cas no
The CAS Registry Mumber 265989-32-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,5,9,8 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 265989-32:
(8*2)+(7*6)+(6*5)+(5*9)+(4*8)+(3*9)+(2*3)+(1*2)=200
200 % 10 = 0
So 265989-32-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H19NO2/c1-14(2)18(21)17(13-15-9-5-3-6-10-15)19(22)20-16-11-7-4-8-12-16/h3-14H,1-2H3,(H,20,22)/b17-13+/i3D,5D,6D,9D,10D
265989-32-0Relevant academic research and scientific papers
Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum
Chen, Bang-Chi,Sundeen, Joseph E.,Guo, Peng,Bednarz, Mark S.,Hangeland, Jon J.,Ahmed, Syed Z.,Jemal, Mohammed
, p. 261 - 270 (2007/10/03)
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.
