26664-86-8

Usage

Common uses

Flavoring agent in fragrance and food industries
Synthesis of pharmaceuticals
Starting material for production of other organic compounds

Physical properties

Sweet, floral scent

Safety concerns

Toxic if ingested or inhaled
Can cause irritation to skin, eyes, and respiratory system

Handling precautions

Careful handling required
Follow proper safety protocols to minimize risk of exposure and potential harm to individuals

Upstream product

• 7228-38-8 5-chloro-1,3-benzodioxole 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 

Downstream Products

• 86358-30-7 benzo[1,3]dioxol-5-ylglyoxylic acid ethyl ester 
• 860404-67-7 2-{benzo[1,3]dioxol-5-yl-[(4-dimethylamino-phenyl)-oxy-imino]-methyl}-chromen-4-one 
• 62502-14-1 3-(3,4-methylenedioxyphenyl)-8,8-dimethyl-4-oxo-4H,8H-benzo[1,2-b:3,4-b']dipyran 
• 107914-36-3 Benzo[1,3]dioxol-5-yl-acetic acid 3-hydroxy-phenyl ester 
• 90-29-9 7-hydroxy-3',4'-methylenedioxyisoflavone 
• 5653-25-8 α-(1,3-benzodioxol-5-yl)-2,4-dihydroxyacetophenone 
• 6845-81-4 3,4-methylenedioxyphenylacetyl chloride 
• 14736-62-0 derrusnin 
• 926008-74-4 {4-[5-(benzo[1,3]dioxol-5-yl)-6-chloropyrimidin-4-ylethynyl]phenyl}dimethylamine 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 

Relevant academic research and scientific papers

Coupling of Reformatsky Reagents with Aryl Chlorides Enabled by Ylide-Functionalized Phosphine Ligands

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives. Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies.

Endothelin antagonists

A compound of formula (I), in which: R1is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2is hydrogen, hydroxy or protected h