26673-30-3

Basic information

• Product Name: 5-Chloro-1-tetralone
• Synonyms: 5-Chloro-1-tetralone;5-Chloro-α-Tetralone;5-chloro-3,4-dihydronaphthalen-1(2H)-one;5-Chloro-tetral-1-on;5-Chloro-3,4-dihydronaphthalen-1(2H)
• CAS NO: 26673-30-3
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.63086
• Mol File: 26673-30-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 65.5-67 °C
• Boiling Point: 306.151 °C at 760 mmHg
• Flash Point: 145.805 °C
• Appearance: /
• Density: 1.248 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Chloro-1-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1-tetralone(26673-30-3)
• EPA Substance Registry System: 5-Chloro-1-tetralone(26673-30-3)

Safety Data

• Hazardous Substances Data: 26673-30-3(Hazardous Substances Data)

Usage

General Description

5-Chloro-1-tetralone is a chemical compound with the molecular formula C10H9ClO. It is a chlorinated derivative of 1-tetralone, often used as a building block in the synthesis of various pharmaceuticals and organic compounds. This chemical is commonly employed as a precursor in the production of drugs and agrochemicals. It is a pale yellow solid with a distinct odor. 5-Chloro-1-tetralone is considered to be a valuable intermediate in the field of organic chemistry due to its versatility and reactivity, and it is commonly utilized in the development of new drug candidates and other biologically active molecules.

InChI:InChI=1/C10H9ClO/c11-9-5-1-4-8-7(9)3-2-6-10(8)12/h1,4-5H,2-3,6H2

Upstream product

• 41823-28-3 5-amino-3,4-dihydronaphthalen-1(2H)-one 
• 51114-73-9 5-nitro-1-tetralone 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 108-90-7 chlorobenzene 
• 62903-14-4 4-(3-chlorophenyl)-4-oxobutyric acid 
• 22991-05-5 4-(3-chlorophenyl)-butyric acid 
• 96-48-0 4-butanolide 
• 90401-68-6 5-Amino-3,4-dihydro-2H-naphthalen-1-one; hydrochloride 
• 68449-31-0 4-(2-chlorophenyl)butanoic acid 

Downstream Products

• 101446-33-7 1-chloro-5-o-tolyl-naphthalene 
• 20816-76-6 5-chloro-1-naphthalenol 
• 90400-98-9 C₁₇H₁₆ClNO₃S 
• 779310-74-6 8-(5-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 101876-57-7 5-chloro-1-(2-methoxy-phenyl)-1,2,3,4-tetrahydro-[1]naphthol 
• 101440-90-8 8-chloro-4-o-tolyl-1,2-dihydro-naphthalene 
• 530093-85-7 2-(5-chloro-3,4-dihydro-1-naphthalenyl)ethyl-4-methylphenylsulphonate 

Relevant articles and documents

NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF

Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

Enantioselective halogenative semi-pinacol rearrangement: Extension of substrate scope and mechanistic investigations

The present Full Paper article discloses a survey of our recent results obtained in the context of the enantioselective halogenation-initiated semi-pinacol rearrangement. Commencing with the fluorination/semi-pinacol reaction first and moving to the heavier halogens (bromine and iodine) second, the scope and limitations of the halogenative phase-transfer methodology will be discussed and compared. An extension of the fluorination/semi-pinacol reaction to the ring-expansion of five-membered allylic cyclopentanols will be also described, as well as some preliminary results on substrates prone to desymmetrization will be given. Finally, the present manuscript will culminate with a detailed mechanistic investigation of the canonical fluorination/semi-pinacol reaction. Our mechanistic discussion will be based on in situ reaction progress monitoring, complemented with substituent effect, kinetic isotopic effect and non-linear behaviour studies.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.