41823-28-3

Basic information

• Product Name: 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE
• Synonyms: 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE;5-Amino-1,2,3,4-tetrahydronaphthalene-1-one;5-Amino-1-tetralone;5-Amino-3,4-dihydro-1(2H)-naphthalenone;5-aMino-2,3,4-trihydronaphthalen-1-one;5-AMino-3,4-dihydro-2H-naphthalen-1-one;5-Amino-3,4-dihydronaphthalen-1(2H)
• CAS NO: 41823-28-3
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 41823-28-3.mol

Chemical Properties

• Melting Point: 119-120℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(41823-28-3)
• EPA Substance Registry System: 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(41823-28-3)

Safety Data

• Hazardous Substances Data: 41823-28-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and chemical products. Its aromatic and heterocyclic structure allows for the creation of a wide range of medicinal compounds.
Used in Organic Chemistry:
In the field of organic chemistry, 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE serves as a building block for the synthesis of complex organic molecules, facilitating the production of specialty chemicals and other advanced materials.
Used in Medicinal Chemistry Research:
5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE is utilized as a research compound in medicinal chemistry to explore its potential biological and pharmacological activities, with the aim of discovering new therapeutic agents and understanding their mechanisms of action.

Upstream product

• 51114-73-9 5-nitro-1-tetralone 
• 90401-71-1 6-mercapto-5-nitro-3,4-dihydro-1(2H)-naphthalenone 
• 119-64-2 tetralin 
• 59604-35-2 6-hydroxy-5-nitrotetralone 
• 438526-37-5 4-(2-aminophenyl)-butyronitrile 
• 7439-89-6 iron 
• 7783-70-2 antimony pentafluoride 
• 29809-14-1 5-nitro-1,2,3,4-tetrahydronaphthalene 
• 90401-69-7 6-(N,N-dimethylthiocarbamoyloxy)-5-nitro-3,4-dihydro-1(2H)-naphthalenone 
• 90401-70-0 6-(N,N-dimethylcarbamoylthio)-5-nitro-3,4-dihydro-1(2H)-naphthalenone 
• 83-55-6 5-amino-1-naphthol 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 26673-30-3 5-chloro-3,4-dihydro-1(2H)-naphthalenone 
• 725233-15-8 N-benzyl-N-(5-cyano-7,8-dihydronaphthalen-1-yl)methanesulfonamide 
• 725233-09-0 N-benzyl-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamide 

Relevant articles and documents

NaI/PPh3-Mediated Photochemical Reduction and Amination of Nitroarenes

A mild transition-metal- and photosensitizer-free photoredox system based on the combination of NaI and PPh3 was found to enable highly selective reduction of nitroarenes. This protocol tolerates a broad range of reducible functional groups such as halogen (Cl, Br, and even I), aldehyde, ketone, carboxyl, and cyano. Moreover, the photoredox catalysis with NaI and stoichiometric PPh3 provides also an alternative entry to Cadogan-type reductive amination when o-nitrobiarenes were used.

NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF

Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

Process for producing 1,5-diaminonaphthalene

The present invention relates to a process for producing 1,5-diaminonaphthalene without formation of 1,8-diaminonaphthalene and not through an unstable nitro imine and nitro enamine as intermediates, the process including the steps of dehydrogenating 5-substituted-1-tetralone to produce a naphthol compound and then aminating the hydroxyl group of the naphthol compound.

Process for the production of 1,5-naphthalenediamine

The invention relates to a process for the production of 1,5-naphthalenediamine and to the intermediates 4-(2-nitrophenyl)butyronitrile, 5-nitro-3,4-dihydro-1(2H)-naphthyl-imine, 5-nitroso-1-naphthylamine, 5-nitro-1-naphthylamine, 4-(2-aminophenyl)-butyronitrile, 5-amino-3,4-dihydro-1(2H)-naphthalene imine, 4-(2-nitrophenyl)ethyl butyrate and 4-(2-nitrophenyl)butyramide obtainable during the process.

Superacid catalyzed reactions of 5-amino-1-naphthol with benzene and cyclohexane

5-Amino-1-naphthol undergoes ionic hydrogenation with cyclohexane and condenses with benzene when reacted in the presence of excess of aluminum halides to give 5-amino-1-tetralone (10) and 5-amino-3-phenyl-1-tetralone, respectively. In CF3SOsu