26733-16-4Relevant academic research and scientific papers
An eco-friendly Co(OAc)2-catalyzed aerobic oxidation of 4-benzylphenols into 4-hydroxybenzophenones
Huang, Jian-Gang,Guo, Ying,Jiang, Jian-An,Liu, Hong-Wei,Ji, Ya-Fei
, p. 7115 - 7124 (2015/02/19)
An undecorated Co(OAc)2-catalyzed aerobic oxidation system has been reported that enables direct transformation of 4-benzylphenols into the corresponding 4-hydroxybenzophenones. The procedure is especially suitable for electron-withdrawing group-containing substrates, which are commonly inefficient to conduct this category of oxidation. Based on well-defined p-benzoquinone methides and the confirmed ethereal intermediate, a plausible mechanism was depicted.
Synthesis, biochemical evaluation and rationalisation of a series of 3,5- dibromo derivatives of 4-hydroxyphenyl ketone-based compounds as probes of the active site of type 3 of 17β-hydroxysteroid dehydrogenase (17β-hsd3) and the role of hydrogen bonding interaction in the inhibition of 17β-HSD3
Olusanjo, Moniola S.,Mashru, Shreena N.,Cartledge, Timothy,Ahmed, Sabbir
scheme or table, p. 604 - 610 (2012/08/28)
We report the synthesis, evaluation and rationalisation of the inhibitory activity of a series of 3,5-dibromo derivatives of 4-hydroxyphenyl ketone as probes of the active site of the type 3 of 17β-hydroxysteroid dehydrogenase (17β-HSD3). The results support the important role of hydrogen bonding interaction in the inhibition of 17β-HSD3.
Regioselective and high-yielding bromination of aromatic compounds using hexamethylenetetramine-bromine
Heravi, Majid M.,Abdolhosseini, Nafiseh,Oskooie, Hossein A.
, p. 8959 - 8963 (2007/10/03)
A regioselective and highly efficient method for bromination of aromatic compounds in the presence of a stoichiometric amount of hexamethylenetetramine- bromine (HMTAB) as an efficient reagent in dichloromethane is reported. The selectivity depends on the temperature and nature of the substituent on the substrate. The reactivity of this reagent was increased by supporting it to silica gel for bromination of less activated compounds.
Alkaline Condensation of Benzotrichloride with Bromophenols
Olszanowski, Andrzej
, p. 1093 - 1098 (2007/10/02)
The reaction of benzotrichloride with 4-alkylphenols is of potential industrial importance to sythesize 2-hydroxy-5-alkylbenzophenones which are industrial oxime extractants used for extraction of copper and other metals.The attempts to obtain 2-hydroxychlorobenzophenone derivatives from 4-chlorophenol and 2,4-dichlorophenol, respectively and benzotrichloride yields besides 2-hydroxychlorobenzophenone, hydroxyketones having fewer atoms of chlorine in the aromatic ring as well as hydroxychlorobenzophenones resulting from the migration of chlorine from the para to the ortho position.In the present paper the reaction between benzotrichloride and bromophenols is studied.
