26750-08-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(1-ADAMANTYL)ETHANOL is used as a catalyst for the change of the load state of MHC (Major Histocompatibility Complex) molecules. This application is crucial in the treatment and diagnosis of various diseases, including cancer, infectious diseases, and autoimmune diseases.
Used in Antiviral Applications:
1-(1-ADAMANTYL)ETHANOL exhibits inhibitory action against several viruses, such as herpes simplex virus type 1, vaccinia virus, vesicular stomatitis virus, fowl plaque virus, respiratory syncytial virus, and Venezuelan encephalitis virus. This makes it a potential candidate for the development of antiviral therapies and treatments.

Upstream product

• 91410-69-4 1-adamantylethanol 
• 1660-04-4 1-acetyladamantane 
• 107-12-0 propiononitrile 
• 75-05-8 acetonitrile 
• 100-47-0 benzonitrile 
• 109-74-0 propyl cyanide 

Downstream Products

• 61876-30-0 N-[1-(1-Adamantyl)ethyl]nicotinamide 
• 26750-08-3 (R)-1-(adamantyl)ethanol 
• 138309-12-3 (S)-1-(1-adamantan-1-yl)ethanol 
• 50795-82-9 3-nitroxyadamantane-1-carboxylic acid 
• 1660-04-4 1-acetyladamantane 
• 69010-56-6 2-adamantan-1-ylpropionic acid methyl ester 
• 1373943-88-4 di[1-(1-adamantyl)ethyl] tosyloxymethylphosphonate 
• 141104-05-4 N-[1-(1-Adamantyl)ethyl]chloroacetamide 
• 52033-51-9 1-adamantylmethylcarbinyl tosylate 

Relevant academic research and scientific papers

Kinetic Resolution of Neopentylic Secondary Alcohols by Cu-H-Catalyzed Enantioselective Silylation with Hydrosilanes

A nonenzymatic kinetic resolution of sterically congested alcohols having a quaternary carbon atom in the β-position is reported. The catalyst system CuCl/NaOtBu/(R,R)-Ph-BPE together with a 3,5-xylyl-substituted tertiary hydrosilane enable enantioselective silylation of the hydroxy group. Several alcohols are obtained with good to excellent selectivity factors, and there are no other known straightforward methods to access these motifs.

Methods of acylating adamantane, tricyclo[5.2.1.02,6], and decalin compounds

An acylating agent of the invention includes (A) a 1,2-dicarbonyl compound or its hydroxy reductant, (B) oxygen, and (C) at least one compound selected from (c1) a metallic compound and (C2) N-hydroxyphthalimide or another imide compound. As the 1,2-dicarbonyl compound or its hydroxy reductant (A), biacetyl, 2,3-butanediolor the like canbeused. As the metallic compound (c1), cobalt acetate, or another cobalt compound, for example, can be employed. By reacting an adamantane derivative or another compound having a methine carbon atom with the acylating agent, an acyl group can be introduced to the methine carbon atom with efficiency.

PROCESS FOR THE PREPARATION OF ORGANIC COMPOUNDS WITH IMIDE CATALYSTS

(A) A compound capable of forming a stable radical and selected from (A1) oxygen-atom-containing compounds each having a carbon-hydrogen bond at the adjacent position to an oxygen atom, (A2) carbonyl-group-containing compounds, and (A3) compounds each having a hydrocarbon group with a methine carbon atom is allowed to react with (B) a radical scavenging compound selected from, for example, (B1) unsaturated compounds, and (B2) compounds each having a hydrocarbon group with a methine carbon atom, in the presence of molecular oxygen by catalysis of, for example, an imide compound shown by the following formula (1): wherein each of R1 and R2 is a hydrogen atom or the like, where R1 and R2 may be combined to form a double bond, or an aromatic or non-aromatic ring; X is an oxygen atom or a hydroxyl group, to yield a product of an addition or substitution reaction of the compound (A) and the compound (B) or its oxidized product. The process can efficiently produce a variety of organic compounds by an addition or substitution reaction using molecular oxygen under mild conditions.