26928-14-3

Upstream product

• 401-58-1 ethyl 2-fluoro-2-iodoacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 210753-68-7 3-(4-Chloro-phenyl)-2-[(4-chloro-phenyl)-hydroxy-methyl]-2-fluoro-3-hydroxy-propionic acid ethyl ester 
• 401-55-8 ethyl bromofluoroacetate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 1479-22-7 ethyl 2-fluoro-3-oxo-3-phenylpropionate 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 459-72-3 ethyl 2-fluoroacetate 
• 565-53-7 ethyl dibromofluoroacetate 
• 7582-61-8 diethyl 2-oxo-3-fluorobutan-1,4-dioate sodium salt 

Downstream Products

• 1221508-35-5 (Z)-3-(4-chloro-phenyl)-2-fluoro-prop-2-en-1-ol 
• 58041-04-6 (Z)-3-(4-chlorophenyl)-2-fluoroacrylaldehyde 

Relevant academic research and scientific papers

CARBOLINE ANTIPARASITICS

The present invention provides Formula (1 ) compounds that are gamma-carbolines, Formula (1) wherein R1 a, R1 b, R1 c, R1d, R2, R3, and "— " are as defined herein; veterinary acceptable salts thereof, and stereoisomers thereof, which act as parasiticides,

A facile and mild approach for stereoselective synthesis of α-fluoro-α,β-unsaturated esters from α-fluoro-β-keto esters via deacylation

The highly stereoselective olefination reaction of α-fluoro-β-keto esters for the synthesis of α-fluoro-α,β-unsaturated esters has been developed. The olefination combines nucleophilic addition, intramolecular nucleophilic addition, and elimination in one step, as well as provides a facile synthetic approach to α-fluoro-α,β-unsaturated esters which are important units in many biologically active compounds and useful precursors in a variety of functional-group transformations.

P[N(i-Bu)CH2CH2]3N: Nonionic Lewis base for promoting the room-temperature synthesis of α,β-unsaturated esters, fluorides, ketones, and nitriles using Wadsworth - Emmons phosphonates

The bicyclic triaminophosphine P(RNCH2CH2) 3N (R = i-Bu, 1c) serves as an effective promoter for the room-temperature stereoselective synthesis of α,β-unsaturated esters, fluorides, and nitriles from a wide array of aromatic, aliphatic, heterocyclic, and cyclic aldehydes and ketones, using a range of Wadsworth-Emmons (WE) phosphonates. Among the analogues of 1c [R = Me (1a), i-Pr (1b), Bn (1d)], 1a and 1b performed well, although longer reaction times were involved, and 1d led to poorer yields than 1c. Functionalities such as cyano, chloro, bromo, methoxy, amino, ester, and nitro were well tolerated. We were able to isolate and characterize (by X-ray means; see above) the reactive WE intermediate species formed from 2b and 1c.

Microwave-assisted one-pot synthesis of α-fluoro-α,β- unsaturated esters under solvent-free conditions

A microwave-assisted approach for the synthesis of α-fluoro-α, β-unsaturated esters from ethyl bromofluoroacetate, aldehydes, and triphenylphosphine in the presence of Zn-Cu under solvent-free conditions was achieved. The reaction was accomplished within

A convenient method for the synthesis of (Z)-α-fluoroacrylates: Lewis base-catalyzed carbonyl fluoroolefination using fluoro(trimethylsilyl)ketene ethyl trimethylsilyl acetal

A highly useful method is established for the stereoselective synthesis of (Z)-α-fluoroacrylates from various aldehydes and fluoro(trimethylsilyl) ketene ethyl trimethylsilyl acetal in the presence of a Lewis base catalyst. The ketene acetal, easily prepared from ethyl fluoroacetate, affords α-fluoroacrylates in high yields with excellent Z stereoselectivities under mild conditions. Copyright

Z-selective or stereospecific alkenylation reaction: A novel synthetic method for α-fluoro-α,β-unsaturated esters

The Z-selective formation of α-fluoro-α,β-unsaturated esters was achieved using the deselenenic acid of the syn-and/or anti-3-aryl-2-fluoro-3-hydroxy-2-organoselanylacetates 3 and 4 with trifluoromethanesulfonic acid. In contrast, the 3-alkyl-substituted propanoates 3f and 4b stereospecifically underwent alkenylation to give the (E)- or (Z)-α-fluoro-α,β-unstaurated esters 5f. We were also successful in the one-pot alkenylation reactions. Copyright

SPIROINDOLINEPIPERIDINE DERIVATIVES

Insecticidal, acaricidal, nematicidal or molluscicidal compounds of formula (I) wherein Y is a single bond, C=O, C=S or C=(O)q where q is 0, 1 or 2; and R1, R2, R3, R4, R8, R9 an

A novel reaction of β,β'-dihydroxy acids or esters with vanadium(V) trichloride oxide. New entry to the stereoselective synthesis of α-fluoro- α,β-unsaturated acids and esters

β,β'-Dihydroxy carboxylic acids and esters, readily prepared from dibromofluoroacetate and aldehydes, underwent deoxygenation, followed by elimination of aldehyde by the action of vanadium(V) trichloride oxide at the reflux temperature of chlorobenzene fo

Zinc-Diethylaluminium Chloride Induced Coupling Reaction of Dibromofluoroacetate with Carbonyl Compounds. New Efficient and Selective Synthesis of α-Bromo-α-fluoro-β-hydroxy and α-Fluoro-β,β'-dihydroxy Esters

Treatment of ethyl dibromofluoroacetate with aldehydes or ketone in the presence of zinc and diethylaluminium chloride at -20 deg C gave rise to the corresponding α-bromo-α-fluoro-β-hydroxy alkanoic acid ethyl esters in good yields, while the use of two equivalents each of aldehyde, zinc, and diethylaluminium chloride in the reaction resulted in a double coupling reaction affording the 1:2 adducts, α-fluoro-β,β'-dihydroxy esters in high yields.

An Expedient Stereoselective Access to (Z)-2-Fluoroalkenoates

The reaction between an aldehyde R-CHO and diethyl 2-oxo-3-fluorobutan-1,4-dioate as its sodium salt EtO2C-CO-CF-CO2Et-,Na+ mainly leads in THF to (Z)-2-fluoroalkenoates R-CH=CF-CO2Et (Z/E>/=80/20), the Z-stereoselectivity depending on the bulk of the R group.Key words: 2-Fluoroalkenoates; (Z)-stereoselective synthesis.