27023-05-8

Basic information

• Product Name: Methyl 4-hydroxy-2,5-diMethylbenzoate
• Synonyms: Methyl 4-hydroxy-2,5-diMethylbenzoate;4-Hydroxy-2,5-dimethylbenzoic Acid Methyl Ester
• CAS NO: 27023-05-8
• Molecular Formula: C10H12O3
• Molecular Weight: 180.20048
• Mol File: 27023-05-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: Methyl 4-hydroxy-2,5-diMethylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-hydroxy-2,5-diMethylbenzoate(27023-05-8)
• EPA Substance Registry System: Methyl 4-hydroxy-2,5-diMethylbenzoate(27023-05-8)

Safety Data

• Hazardous Substances Data: 27023-05-8(Hazardous Substances Data)

Usage

Uses

Methyl 4-?Hydroxy-?2,?5-?dimethylbenzoate is a reagent that is used in the synthesis of N-Benzoyl-2-methylindole-3-acetic Acids, which are prostaglandin (PG) D2 receptor antagonists.

Upstream product

• 13730-55-7 methyl 2,5-dimethylbenzoate 
• 58106-26-6 4-methoxy-2,5-dimethylbenzoic acid 
• 67-56-1 methanol 
• 27021-04-1 4-hydroxy-2,5-dimethyl-benzoic acid 
• 114971-53-8 4-iodo-2,5-dimethyl-phenol 

Relevant articles and documents

Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide

The oxidation of arenes by the reagent phthaloyl peroxide provides a new method for the synthesis of phenols. A new, more reactive arene oxidizing reagent, 4,5-dichlorophthaloyl peroxide, computationally predicted and experimentally determined to possess enhanced reactivity, has expanded the scope of the reaction while maintaining a high level of tolerance for diverse functional groups. The reaction proceeds through a novel "reverse-rebound" mechanism with diradical intermediates. Mechanistic insight was achieved through isolation and characterization of minor byproducts, determination of linear free energy correlations, and computational analysis of substituent effects of arenes, each of which provided additional support for the reaction proceeding through the diradical pathway.

AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3 R4, R5 and R6 are each hydrogen, halogen, lower alkyl or lower alkoxy; R7 and R8 are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R9 is -C(O)-R10, -A1-C(O)-R10, -O-A2-C(O)-R10 or a tetrazol-5-yl group, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.