27032-03-7Relevant articles and documents
Soft antimicrobial agents: Synthesis and activity of labile environmentally friendly long chain quaternary ammonium compounds
Thorsteinsson, Thorsteinn,Másson, Már,Kristinsson, Karl G.,Hjálmarsdóttir, Martha A.,Hilmarsson, Hilmar,Loftsson, Thorsteinn
, p. 4173 - 4181 (2003)
A series of soft quaternary ammonium antimicrobial agents, which are analogues to currently used quaternary ammonium preservatives such as cetyl pyridinium chloride and benzalkonium chloride, were synthesized. These soft analogues consist of long alkyl chain connected to a polar headgroup via chemically labile spacer group. They are characterized by facile nonenzymatic and enzymatic degradation to form their original nontoxic building blocks. However, their chemical stability has to be adequate in order for them to have antimicrobial effects. Stability studies and antibacterial and antiviral activity measurements revealed relationship between activity, lipophilicity, and stability. Their minimum inhibitory concentration (MIC) was as low as 1 μg/mL, and their viral reduction was in some cases greater than 6.7 log. The structure-activity studies demonstrate that the bioactive compounds (i.e., MIC for Gram-positive bacteria of 10μg/mL) have an alkyl chain length between 12 and 18 carbon atoms, with a polar headgroup preferably of a small quaternary ammonium group, and their acquired inactivation half-life must be greater than 3 h at 60 °C.
C(sp3)-H Activation without a Directing Group: Regioselective Synthesis of N-Ylide or N-Heterocyclic Carbene Complexes Controlled by the Choice of Metal and Ligand
Cross, Warren B.,Razak, Sunnah,Singh, Kuldip,Warner, Andrew J.
, p. 13203 - 13209 (2014)
N-Ylide complexes of Ir have been generated by C(sp3)-H activation of α-pyridinium or α-imidazolium esters in reactions with [Cp?IrCl2]2 and NaOAc. These reactions are rare examples of C(sp3)-H activation withou
1,3-Dipolar cycloaddition of azinium ylides to alkynyl hetarenes: A synthetic route to indolizine and pyrrolo[2,1-a]isoquinoline based heterobiaryls
Nelina-Nemtseva, Julia I.,Gulevskaya, Anna V.,Pozharskii, Alexander F.,Nguyen, Huong T.L.,Filatova, Ekaterina A.
, p. 2327 - 2335 (2016/04/19)
For the first time, π-deficient alkynyl hetarenes were used as dipolarophiles in a 1,3-dipolar cycloaddition reaction with in situ generated azinium ylides. A three-component reaction of pyridine or isoquinoline, ethyl chloroacetate and alkynyl hetarene (
