27038-48-8

Basic information

• Product Name: Furo[2,3-b]pyridin-3(2H)-one
• Synonyms: Furo[2,3-b]pyridin-3(2H)-one
• CAS NO: 27038-48-8
• Molecular Formula: C7H5NO2
• Molecular Weight: 135.1201
• Mol File: 27038-48-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Furo[2,3-b]pyridin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-b]pyridin-3(2H)-one(27038-48-8)
• EPA Substance Registry System: Furo[2,3-b]pyridin-3(2H)-one(27038-48-8)

Safety Data

• Hazardous Substances Data: 27038-48-8(Hazardous Substances Data)

Usage

General Description

Furo[2,3-b]pyridin-3(2H)-one is a chemical compound with a heterocyclic structure, consisting of a furo[2,3-b]pyridine ring fused with a pyridin-3(2H)-one moiety. It is a heterocyclic compound that can be used in various chemical reactions and synthetic pathways. The compound has potential applications in the pharmaceutical industry, particularly in the development of new drugs and pharmaceutical products. Its unique structure and properties make it a versatile building block in organic synthesis, with potential for further development and research.

Upstream product

• 27038-46-6 3-(2-bromoacetyl)pyridin-2(1H)-one 
• 2942-59-8 2-chloronicotinic acid 
• 851620-39-8 furo[2,3-b]pyridin-3(2H)-one hydrochloride 
• 1452-94-4 ethyl 2-chloronicotinate 
• 119293-09-3 ethyl 3-ethoxycarbonylmethoxyfuro<2,3-b>pyridine-2-carboxylate 
• 119293-13-9 ethyl 3-ethoxyfuro<2,3-b>pyridine-2-carboxylate 
• 119293-17-3 3-Ethoxy-furo[2,3-b]pyridine-2-carboxylic acid 
• 109274-83-1 ethyl 3-hydroxyfuro<2,3-b>pyridine-2-carboxylate 
• 1279893-97-8 ethyl 3-oxo-2,3-dihydrofuro[2,3-b]pyridine-2-carboxylate 
• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 
• 119292-93-2 3-ethoxyfuro<2,3-b>pyridine 

Downstream Products

• 109274-90-0 3-Methyl-furo[2,3-b]pyridine 
• 1629241-51-5 4-(3-(3-methoxypropoxy)phenyl)-3,4-dihydropyrido[3',2':4,5]furo[3,2-d]pyrimidine-2(1H)-thione 
• 1620518-04-8 C₂₁H₁₆N₄O₂S 
• 1620518-03-7 R-4-(3-(3-methoxypropoxy)phenyl)-3,4-dihydropyrido[3',2':4,5]furo[3,2-d]pyrimidine-2(1H)-thione 
• 870061-94-2 2,3-dihydrofuro[2,3-b]pyridin-3-amine 
• 1421618-78-1 2-(2,4-dichloro-phenyl)-N-(2,3-dihydro-furo[2,3-b]pyridin-3-yl)-acetamide 
• 1421618-79-2 2-(2,4-dichloro-phenyl)-N-(2,3-dihydro-furo[2,3-b]pyridin-3-yl)-acetamide 
• 1421618-76-9 2-(2,4-Dichloro-phenyl)-N-(2,3-dihydro-furo[2,3-b]pyridin-3-yl)-acetamide 
• 151384-57-5 2-[3-Hydroxy-3H-furo[2,3-b]pyridin-(2E)-ylidenemethyl]-benzoic acid methyl ester 

Relevant articles and documents

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as starting points for the development of high-quality CAMKK2 chemical probes, we utilized a hinge-binding scaffold hopping strategy to design new CAMKK2 inhibitors. Starting from the potent but promiscuous disubstituted 7-azaindole GSK650934, a total of 32 compounds, composed of single-ring, 5,6-, and 6,6-fused heteroaromatic cores, were synthesized. The compound set was specifically designed to probe interactions with the kinase hinge-binding residues. Compared to GSK650394 and STO-609, 13 compounds displayed similar or better CAMKK2 inhibitory potency in vitro, while compounds 13g and 45 had improved selectivity for CAMKK2 across the kinome. Our systematic survey of hinge-binding chemotypes identified several potent and selective inhibitors of CAMKK2 to serve as starting points for medicinal chemistry programs.

BENZOFURAN AMIDES AND HETEROAROMATIC ANALOGUES THEREOF FOR USE IN THERAPY

The present invention relatesto a pharmaceutical composition comprising acompound of the formula Ias described belowor a tautomeror a pharmaceutically acceptable salt thereof; to the compound of the formula Ias described below or a tautomer or a phar- mac

SPIROFUROPYRIDINE ARYL DERIVATIVES

Compounds of formula (I): and pharmaceutically-acceptable salts thereof, wherein: Ar is a moiety of formula (II) or (III): and A, B, and R1 are as defined in the specification, compositions containing such compounds and the use of such compounds and compositions for use in therapy.