27064-89-7

Usage

Uses

Used in Pharmaceutical Research:
1-(4-Fluoro-alpha-phenylbenzyl)piperazine is used as a research compound for the development of medications for psychiatric disorders. Its unique structure, including a fluorine atom and a phenyl group, makes it a promising candidate for the treatment of mood and anxiety disorders.
Used in Psychopharmacological Studies:
1-(4-Fluoro-alpha-phenylbenzyl)piperazine is used as a psychopharmacological agent to understand the mechanisms of action of various psychoactive substances. Its potential applications in this field can contribute to the advancement of knowledge in psychopharmacology and the development of new therapeutic approaches for mental health conditions.
Used in Drug Development:
1-(4-Fluoro-alpha-phenylbenzyl)piperazine is used as a starting point for the development of new drugs targeting psychiatric disorders. Its potential therapeutic effects, as well as its structural features, make it a valuable compound for further research and optimization in the drug development process.

InChI:InChI=1/C17H19FN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2

Upstream product

• 352-13-6 4-flourophenylmagnesium bromide 
• 345-83-5 4-fluorobenzophenone 
• 100-52-7 benzaldehyde 
• 149099-27-4 4-fluorobenzhydrol 
• 110-85-0 piperazine 
• 365-21-9 1-(chlorophenylmethyl)-4-fluorobenzene 

Downstream Products

• 65214-93-9 1-[3-{4-[α-(4-fluorophenyl)-α-phenylmethyl]-1-piperazinyl}propyl]-1,3-dihydro-2H-benzimidazol-2-one 
• 1219624-18-6 1-(2-{4-[(4-fluorophenyl)(phenyl)methyl]piperazin-1-yl}-2-oxoethyl)-3,3-diphenylpyrrolidin-2-one 
• 661453-42-5 C₃₂H₃₁FN₂O 
• 68732-31-0 5-[4-(4-fluoro-benzhydryl)-piperazin-1-ylmethyl]-2-methyl-1-propyl-1H-benzoimidazole 
• 118420-24-9 (E)-N-(4-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperazin-1-yl}-butyl)-3-pyridin-3-yl-acrylamide 
• 101477-51-4 1-(2,3,4-trimethoxybenzyl)-4-(4-fluorobenzhydryl)piperazine fumarate 
• 114022-26-3 1-[(4-Fluoro-phenyl)-phenyl-methyl]-4-(2,4,6-trimethoxy-benzyl)-piperazine; compound with (E)-but-2-enedioic acid 
• 101477-46-7 1-(2,4-Dimethoxybenzyl)-4-(4-fluorobenzhydryl)-piperazine fumarate 
• 114022-29-6 (4-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-phenyl)-dimethyl-amine; compound with (E)-but-2-enedioic acid 
• 118419-73-1 4-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperazin-1-yl}-butylamine 
• 114022-28-5 1-Benzo[1,3]dioxol-5-ylmethyl-4-[(4-fluoro-phenyl)-phenyl-methyl]-piperazine; hydrochloride 

Relevant academic research and scientific papers

Design, synthesis, and molecular docking study of new piperazine derivative as potential antimicrobial agents

Herein, we describe the successful design and synthesis of seventeen new 1,4-diazinanes, compounds commonly known as piperazines. This group of piperazine derivatives (3a-q) were fully characterized by 1H NMR, 13C NMR, FT-IR, and LCMS spectral techniques. The molecular structure of piperazine derivative (3h) was further established by single crystal X-ray diffraction analysis. All reported compounds were evaluated for their antibacterial and antifungal potential against five bacterial (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa) and two fungal strains (Candida albicans and Cryptococcus neoformans). The complete bacterial screening results are provided. As documented, piperazine derivative 3e performed the best against these bacteria. Additionally, data obtained during molecular docking studies are very encouraging with respect to potential utilization of these compounds to help overcome microbe resistance to pharmaceutical drugs, as explicitly noted in this manuscript.

Synthesis and Anticancer Activity of 1-(1H -Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives

Several new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by 1H NMR, IR, mass spectra, and elemental analysis. These compounds were further evaluated for their anticancer activity, and most of them were found to have moderate-to-potent antiproliferative activities against Hela, A-549, and ECA-109 cancer cell lines in vitro.

HETEROCYCLIC COMPOUND AND H1 RECEPTOR ANTAGONIST

A heterocyclic compound useful as an antiallergic agent is provided. A compound represented by the following formula (1) or a salt thereof: wherein the ring A is a homocyclic or heterocyclic ring; the ring B is a heterocyclic ring which contains G and nitrogen atom N as constituent atoms thereof, wherein G is CH or N; R1 is a carbonyl group or an alkylene group; R2a and R2b are an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; X is an oxygen atom or a sulfur atom; Z is a hydroxyl group, an alkoxy group, a cycloalkyloxy group, an aryloxy group, an aralkyloxy group, an amino group, or an N-substituted amino group; and n is 0 or 1; with the proviso that when the ring A is a benzene ring or when the ring B is a piperazine ring, R1 is an alkylene group which may have a substituent.

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.

Process for producing piperazinesulfonamide derivatives and salts thereof

A process for advantageously preparing a piperazinesulfonamide derivative represented by the general formula (III): wherein R1 is hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group or amino group; R2 is a phenyl group which may have as substituents on its phenyl ring 1 to 3 groups selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group and amino group, 2-pyridyl group, 3-pyridyl group or 4-pyridyl group; each of R3 and R4 is independently hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, a hydroxyalkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a phenyl group which may be substituted; and Y is an alkylene group having 1 to 12 carbon atoms, and a salt thereof.