73276-84-3Relevant academic research and scientific papers
Synthesis, characterization, and copper(II) chelates of 1,11-dithia-4,8-diazacyclotetradecane
Taschner, Ian S.,Walker, Tia L.,Dehaan, Hunter S.,Schrage, Briana R.,Ziegler, Christopher J.,Taschner, Michael J.
, p. 11091 - 11102 (2019/09/30)
Synthesis of 1,11-dithia-4,8-diazacyclotetradecane (L1), a constitutional isomer of the macrocyclic [14]aneN2S2 series, is accompanied with reaction and method optimization. Chelation of L1 with copper(II) provided assessment of latt
PHOSPHORAMIDATE ALKYLATOR PRODRUGS
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Page/Page column 121, (2008/06/13)
Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
Design and synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates by the use of SNAr reaction of 2-nitro-5-fluorobenzoate precursor as key reaction
Iida, Hirokazu,Hayashi, Naoto,Lown, J. William,Matsumoto, Kiyoshi
, p. 693 - 711 (2007/10/03)
The design and synthesis of a series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates as DNA minor groove binders are described. To introduce polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore, SNA
Synthesis of polyaminoalkyl substituted conjugates of pyrrolo[2,1- c][1,4]benzodiazepine involving S(N)Ar reaction of 2-nitro-5-fluorobenzoate precursors
Matsumoto, Kiyoshi,Iida, Hirokazu,Lown, J. William
, p. 1015 - 1020 (2007/10/03)
A synthetic procedure is described for conjugating polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore in order to alter its characteristic DNA sequence binding preference. To this end S(N)Ar reactions of 2-nitro-5-fluorobenzoate
