27152-62-1

Upstream product

• 2298-49-9 N-methyl-3-oxo-N-(3-oxo-3-phenylpropyl)-3-phenylpropan-1-aminium chloride 
• 50-00-0 formaldehyd 
• 593-51-1 methylamine hydrochloride 
• 98-86-2 acetophenone 
• 768-03-6 Phenyl vinyl ketone 
• 74-89-5 methylamine 
• 29636-75-7 3-bromo-1-phenylpropan-1-one 
• 21970-65-0 3-(benzyl-methyl-amino)-1-phenylpropan-1-one 
• 28289-54-5 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine 
• 207395-42-4 1-(N-formyl-N-methyl)amino-3-phenylpropan-2-one 
• 936-59-4 3-chloropropiophenone 
• 24070-51-7 β-iodopropiophenone 

Downstream Products

• 103756-12-3 3,3’-(methylazanediyl)bis(1-phenylpropan-1-one) 
• 42142-52-9 3-methylamino-1-phenylpropan-1-ol 
• 85975-36-6 N-(Methyl-β-benzoylethyl)glycine methyl ester hydrobromide 
• 1939-17-9 N-<3-Phenyl-propin-(2)-yl>-N-<3-hydroxy-3-phenyl-propyl>-methylamin 
• 1250437-76-3 9,10-dihydro-N-methyl-9-oxo-N-(3-oxo-3-phenylpropyl)acridine-4-carboxamide 
• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 

Relevant academic research and scientific papers

Design, synthesis and evaluation of substituted N-(3-arylpropyl)-9,10- dihydro-9-oxoacridine-4-carboxamides as potent MDR reversal agents in cancer

A novel class of molecules with structure N-(3-arylpropyl)-9,10-dihydro-9- oxoacridine-4-carboxamides (20-29) were designed by generating a pharmacophore for potent MDR reversal activity using phase drug design software. The designed molecules were synthesized by a novel synthesis route and evaluated for their inhibitory effects on the transport activity of P-glycoprotein (P-gp) by standard Hoechst 33342 assay method. Based on the pIC50 values of ten title compounds screened, three compounds exhibited better activity as compared to Verapamil used as standard.

Microwave-assisted synthesis and evaluation of substituted aryl propyl acridone-4-carboxamides as potential chemosensitizing agents for cancer

A novel class of compounds with structure Aryl propyl acridone-4- carboxamides were synthesized by conventional and microwave (MW) irradiation methods and evaluated for their inhibitory effects on the transport activity of P- glycoprotein (P-gp) by standard Hoechst 33342 assay method. The title compounds with phenoxy substitution exhibited better activity.

Oxidative reactions of azines. 9. Cascade and stage oxidation of 1,4-disubstituted 1,2,3,6-tetra-hydropyridines by potassium permanganate

A general scheme was developed for the cascade and stage oxidation of 1,4-disubstituted 1,2,3,6-tetrahydropyridines by potassium permanganate, based on the successive oxidation of the allylic triad of carbon atoms in the piperideine ring. In the case of 4

Efficient asymmetric hydrogenation of β- and γ-amino ketone derivatives leading to practical synthesis of fluoxetine and eprozinol

N-(Methylcarbamoyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)me thyl]pyrrolidine (MCCPM)- and N-(tert-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphin o)methyl]pyrrolidine (BCPM)-rhodium(I) complexes were efficient catalysts for asymmetric hydrogenations of β- and γ-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient syntheses of fluoxetine and eprozinol from intermediate optically active amino alcohols.

KINETICS AND MECHANISM OF REACTION OF AMINES WITH β-BROMOPROPIOPHENONE

The reaction of β-bromopropiophenone with different amines in acetonitrile at 25 deg C was studied.It was found that in the case of primary and secondary amines, the end products of the reaction are β-aminopropiophenones, which form via the intermediate phenyl vinyl ketone.In the case of tertiary amines, the reaction ends at the stage of the formation of phenyl vinyl ketone.The reactivity of the amines in the formation of phenyl vinyl ketone is preferentially determined by their basicity.