27251-84-9 Usage
Description
[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid, commonly known as ribonucleic acid (RNA), is a vital molecule in the process of protein synthesis and gene expression within living organisms. It is composed of a ribose sugar linked to a phosphate group and a nucleobase, playing a pivotal role in the transfer of genetic information from DNA to proteins. RNA is intricately involved in various cellular processes, including transcription, translation, and regulation of gene expression, making it an indispensable component of all living cells. Its structural complexity and diverse functions render it a significant target for research in the fields of biochemistry and molecular biology.
Uses
Used in Biochemical Research:
[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid is used as a subject of study in biochemical research for its fundamental role in the molecular mechanisms of life. It aids in understanding the processes of transcription and translation, as well as the regulation of gene expression.
Used in Molecular Biology:
In molecular biology, [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid is utilized for its involvement in the central dogma of molecular biology, which includes the flow of genetic information within the cell. It is instrumental in the development of techniques and methodologies for genetic manipulation and analysis.
Used in Pharmaceutical Development:
[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid is employed in the pharmaceutical industry for the development of drugs that target RNA molecules, potentially leading to treatments for a variety of diseases, including viral infections and genetic disorders.
Used in Diagnostics:
In the diagnostics field, [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid is used for the detection and analysis of RNA-based biomarkers, which can indicate the presence or progression of certain diseases, contributing to early diagnosis and personalized medicine approaches.
Used in Synthetic Biology:
[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid is utilized in synthetic biology for the design and construction of novel genetic systems and devices, enabling the creation of organisms with new or enhanced functions for various applications, including bioproduction and environmental remediation.
Used in Nanotechnology:
In nanotechnology, [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid is applied in the development of nanoscale devices and materials that leverage the unique properties of RNA, such as its ability to fold into complex structures and participate in molecular recognition processes.
Used in Bioinformatics:
[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphonic acid is used in bioinformatics for the development of computational models and algorithms to analyze and predict the structure, function, and dynamics of RNA molecules, facilitating a deeper understanding of their roles in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 27251-84-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,2,5 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 27251-84:
(7*2)+(6*7)+(5*2)+(4*5)+(3*1)+(2*8)+(1*4)=109
109 % 10 = 9
So 27251-84-9 is a valid CAS Registry Number.
27251-84-9Relevant articles and documents
Kinetic and NMR spectroscopic study of the chemical stability and reaction pathways of sugar nucleotides
Jaakkola, Juho,Nieminen, Anu,Kivel?, Henri,Korhonen, Heidi,T?htinen, Petri,Mikkola, Satu
, p. 178 - 193 (2020/12/21)
The alkaline cleavage of two types of sugar nucleotides has been studied by 1H and 31P NMR in order to obtain information on the stability and decomposition pathways in aqueous solutions under alkaline conditions. The reaction of glucose 1-UDP is straightforward, and products are easy to identify. The results obtained with ribose 5-UDP and ribose 5-phosphate reveal, in contrast, a more complex reaction system than expected, and the identification of individual intermediate species was not possible. Even though definite proof for the mechanisms previously proposed could not be obtained, all the spectroscopic evidence is consistent with them. Results also emphasise the significant effect of conditions, pH, ionic strength, and temperature, on the reactivity under chemical conditions.
Chemical and enzymatic synthesis of the alginate sugar nucleotide building block: GDP-D-mannuronic acid
Beswick, Laura,Ahmadipour, Sanaz,Dolan, Jonathan P.,Rejzek, Martin,Field, Robert A.,Miller, Gavin J.
, (2019/09/30)
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β-Glucose-1,6-Bisphosphate stabilizes pathological phophomannomutase2 mutants in vitro and represents a lead compound to develop pharmacological chaperones for the most common disorder of glycosylation, PMM2-CDG
Monticelli, Maria,Liguori, Ludovica,Allocca, Mariateresa,Andreotti, Giuseppina,Cubellis, Maria Vittoria
, (2019/10/22)
A large number of mutations causing PMM2-CDG, which is the most frequent disorder of glycosylation, destabilize phosphomannomutase2. We looked for a pharmacological chaperone to cure PMM2-CDG, starting from the structure of a natural ligand of phosphomannomutase2, α-glucose-1,6-bisphosphate. The compound, β-glucose-1,6-bisphosphate, was synthesized and characterized via 31P-NMR. β-glucose-1,6-bisphosphate binds its target enzyme in silico. The binding induces a large conformational change that was predicted by the program PELE and validated in vitro by limited proteolysis. The ability of the compound to stabilize wild type phosphomannomutase2, as well as frequently encountered pathogenic mutants, was measured using thermal shift assay. β-glucose-1,6-bisphosphate is relatively resistant to the enzyme that specifically hydrolyses natural esose-bisphosphates.
