272785-87-2

Upstream product

• 174467-01-7 9-[(2R,3S,4S,5R)-3-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-4-(5-nitro-pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one 
• 3634-56-8 isopropyldimethylsilyl chloride 
• 272785-86-1 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(5-nitropyridyl-2-disulfanyl)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine 
• 121-45-9 phosphorous acid trimethyl ester 

Relevant academic research and scientific papers

Preparation, hydrolysis and intramolecular transesterification of 3'- deoxy-3'-thioinosine 3'-S-dimethylphosphorothiolate

The hydrolytic reactions of the dimethyl ester of 3'-deoxy-3'- thioinosine 3'-S-phosphorothiolate have been followed over a wide acidity range by HPLC. At pH > 3, only hydroxide ion catalyzed isomerization to the 2'-dimethylphosphate takes place, whereas under more acidic conditions hydrolysis to the 2'-monomethylphosphate and 3'-S-monomethylphosphorothiolate competes. The latter is the only product accumulating in very acidic solutions (1 M hydrochloric acid). Mechanisms of the reactions are discussed.