52333-45-6

Usage

Molecular Structure

2-(4-chlorophenyl)[1,3]oxazolo[4,5-b]pyridine has a complex molecular structure, consisting of a pyridine ring fused to an oxazole ring and a 4-chlorophenyl group attached to the 2nd position of the pyridine ring.

Chemical Family

It belongs to the oxazolo[4,5-b]pyridine family, which is a group of chemical compounds known for their potential applications in medicinal chemistry and pharmaceuticals.

4-Chlorophenyl Group

The compound contains a 4-chlorophenyl group, which is a chlorine atom attached to a phenyl ring. This functional group can influence the compound's biological activity and properties.

Potential Applications

Due to its structural features, 2-(4-chlorophenyl)[1,3]oxazolo[4,5-b]pyridine has potential applications in the field of medicinal chemistry and pharmaceuticals. Its structure can be tailored for specific biological activities, making it a promising candidate for drug development or as a research tool.

Bioactivity

The compound's structure suggests that it may have some level of bioactivity, which means it could interact with biological systems and potentially produce therapeutic effects or other biological responses.

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 273-97-2 oxazolo<4,5-b>pyridine 
• 16867-03-1 2-amino-3-hydroxypyridine 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 134377-81-4 2-(4-CHLOROPHENYL)-5-BUTYRYLOXAZOLO[4,5-b]PYRIDINE 
• 134377-82-5 2-(4-CHLOROPHENYL)-7-BUTYRYLOXAZOLO[4,5-b]PYRIDINE 

Relevant academic research and scientific papers

Molecular modeling, density functional theory, ADME prediction and antimicrobial activity studies of 2-(substituted)oxazolo[4,5-: B] pyridine derivatives

In this study, the antimicrobial activities of previously synthesized 2-(substituted)oxazolo[4,5-b]pyridine derivatives toward six bacteria strains and twelve related drug-resistant isolates, and one fungus strain and two related drug-resistant isolates w

Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.

In vitro and in silico evaluation of 2-(substituted phenyl) oxazolo[4,5-b]pyridine derivatives as potential antibacterial agents

Increasing resistance to antibiotics is a major problem worldwide and stimulates the development of new bacterial inhibitors. Series of oxazolo[4,5-b]pyridine synthesized in our lab was examined to screen them as potential antimicrobial agents. The antimi

Acid-Catalyzed, Silica-Supported, One-Pot Benzoylation Route to Synthesize 2-(Substituted Phenyl)oxazolo[4,5-b]pyridines under Ambient Conditions

The present paper describes a silica-supported, perchloric-acid-catalyzed, efficient protocol for the synthesis of 2-(phenyl)oxazolo[4,5-b]pyridine derivatives. This strategy has high conversion, simple workup procedures, ambient conditions, short reactio

A rapid method for the preparation of 2-substituted oxazolo[4,5-b]pyridines using microwave-assisted direct condensation reactions

The condensation reaction of 2-amino-3-hydroxypyridine with different carboxylic acids by microwave-assisted heating is a fast method for producing libraries based on fused 2-substituted oxazolo[4,5-b]pyridines in moderate to good yields.

Unprecedentedly mild direct Pd-catalyzed arylation of oxazolo[4,5-b] pyridine

Pd-catalyzed C-2 arylation of oxazolo[4,5-b]pyridine proceeds efficiently at 30°C and tolerates a variety of aryl halides, including derivatized amino acids for which no racemization was observed during the reaction. Experimental evidence for facile depro

Process for the synthesis of oxazolopyridine compounds

Process for the synthesis of compounds of formula (I): STR1 their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; R1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; 0≤m≤2; R2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group STR2 such that: R3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, 0≤n≤5 employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.

2-Aryloxazolo- et pyridines: synthese et acylation par substitution radicalaire

Homolytic acylation of protonated 2-aryloxazolo- and pyridines by butyraldehyde and benzaldehyde, as a source of acyl radical, gives products substituted at α and γ position in satisfactory yields.The factors affecting mono- and poly-substit

Analgesic oxazolopyridine compounds

Compound of general formula (I): STR1 in which: X, Y, Z and T each represent, independently of one another, a nitrogen atom, a --CH= group or a group CW, in which W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.