27301-77-5

Usage

Uses

Used in Pharmaceutical Applications:
1-(4-chlorophenyl)-3-methyl-1H-pyrazole is used as a therapeutic agent for the treatment of neurological and psychiatric disorders such as anxiety, depression, and pain. Its selective inhibition of FAAH can modulate the levels of endocannabinoids, which are involved in the regulation of mood, appetite, and pain perception.
Used in Research Applications:
1-(4-chlorophenyl)-3-methyl-1H-pyrazole is also used as a tool compound in the research of the endocannabinoid system and its role in modulating neurotransmitter signaling pathways. This helps scientists better understand the mechanisms underlying various neurological and psychiatric conditions and develop new therapeutic strategies.
Used in Drug Development:
In the pharmaceutical industry, 1-(4-chlorophenyl)-3-methyl-1H-pyrazole serves as a lead compound for the development of new drugs targeting the FAAH enzyme. Its selective inhibition of FAAH can potentially lead to the creation of novel medications for the treatment of a range of neurological and psychiatric disorders.

Upstream product

• 1453-58-3 3-Methylpyrazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 27301-76-4 1-(4-chlorophenyl)-3-methyl-4,5-dihydropyrazole 

Downstream Products

• 875656-69-2 4-chloromethyl-1-(4-chlorophenyl)-3-methyl-1H-pyrazole 

Relevant academic research and scientific papers

TBHP/Cu(OAc)2 mediated oxidation of pyrazolines: A convenient method for the preparation of pyrazoles

An efficient and simple oxidative protocol has been developed for the preparation of pyrazoles from pyrazolines mediated by TBHP/Cu(OAc)2 at room temperature. The present protocol has been successfully applied for the preparation of various pyrazole compounds from heterocyclic pyrazolines.

A manganese/copper bimetallic catalyst for C-N coupling reactions under mild conditions in water

An efficient and convenient bimetallic MnF2/CuI catalyst in combination with trans-1,2-diaminocyclohexane has been developed for the cross-coupling of nitrogen heterocycles with aryl halides in water at moderate temperature. A variety of nitrogen nucleophiles including pyrazole, 7-azaindole, indazole, indole, pyrrole and imidazole afforded the corresponding products in moderate to good yields (up to 94%) under the described arylation conditions.

Manganese-catalyzed cross-coupling reactions of nitrogen nucleophiles with aryl halides in water

A facile and convenient strategy for the assembly of N-arylated heterocycles has been demonstrated using a MnCl2·4H 2O/trans-1,2-diaminocyclohexane catalyst and K3PO 4 as the base in water.