27309-45-1

Upstream product

• 71319-20-5 (4-methylphenyl)(2-nitrophenyl)methanone 
• 703-61-7 2,4-dichloroquinoline 
• 195062-57-8 p-tolylboronic pinacol ester 
• 610-14-0 2-nitrobenzyl chloride 
• 36192-63-9 2-amino-4'-methylbenzophenone 
• 36188-57-5 N-(2-(4-methylbenzoyl)phenyl)acetamide 
• 552-16-9 ortho-nitrobenzoic acid 
• 106015-76-3 4-(p-tolyl)-2-(1H)-quinolinone 

Downstream Products

• 120301-19-1 2-Piperazin-1-yl-4-p-tolyl-quinoline 
• 105189-11-5 2-[4-(2-hydroxyethyl)-1-piperazinyl]-4-(4-methylphenyl)quinoline 
• 120301-20-4 2-(4-Butyl-piperazin-1-yl)-4-p-tolyl-quinoline 

Relevant academic research and scientific papers

Palladium-catalyzed c-4 selective coupling of 2,4-dichloropyridines and synthesis of pyridine-based dyes for live-cell imaging

An alternative process of Pd-catalyzed C-4 selective coupling of 2,4-dichloropyridines with boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in moderate to good yields. After further arylation, 21 examples of C-2, C-4 diarylated pyridines with a significant photophysical property were obtained, which were applied as pyridine-based dyes into live-cell imaging with good biocompatibility and low toxicity.

2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, processes for the preparation thereof, and pharmaceutical composition containing the same

Compounds of the formula: STR1 wherein R1 represents fluorine atom at the para position, chlorine atom at the para position, methyl group at the para position or trifluoromethyl group at the para or meta position; and R2 represents h