273399-95-4

Basic information

• Product Name: (6-CHLORO-1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE
• Synonyms: (5-Chloro-1H-benzo[d]iMidazol-2-yl)MethanaMine;[(5-chloro-1H-benzimidazol-2-yl)methyl]amine diHYDROCHLORIDE Salt;(6-CHLORO-1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE;C-(6-CHLORO-1H-BENZIMIDAZOL-2-YL)-METHYLAMINE;1H-Benzimidazole-2-methanamine,5-chloro-(9CI);1-(6-Chloro-1H-benzimidazol-2-yl)methanamine;[(5-chloro-1H-benzimidazol-2-yl)methyl]amine dihydrochloride;1-(5-chloro-1H-benzimidazol-2-yl)methanamine
• CAS NO: 273399-95-4
• Molecular Formula: C₈H₈ClN₃
• Molecular Weight: 181.62222
• Product Categories: BENZIMIDAZOLE
• Mol File: 273399-95-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 417.3 °C at 760 mmHg
• Flash Point: 206.2 °C
• Appearance: /
• Density: 1.429 g/cm³
• Vapor Pressure: 3.58E-07mmHg at 25°C
• Refractive Index: 1.716
• PKA: 11.96±0.29(Predicted)
• CAS DataBase Reference: (6-CHLORO-1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (6-CHLORO-1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE(273399-95-4)
• EPA Substance Registry System: (6-CHLORO-1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE(273399-95-4)

Safety Data

• Hazardous Substances Data: 273399-95-4(Hazardous Substances Data)

Usage

General Description

(6-Chloro-1H-benzo[d]imidazol-2-yl)methanamine is a chemical compound that belongs to the class of organic compounds known as benzimidazoles, which are organic compounds containing a benzene ring fused to an imidazole ring. This specific compound is characterized by a methanamine group attached to the benzimidazole ring in the 2-position and a chlorine atom in the 6-position of the benzene ring. The presence of the amine and chlorine groups can potentially make this compound reactive and susceptible to reactions, creating different derivatives. However, detailed information regarding its properties, reactivity, uses, hazards, or safety is not widely available, implying that it might not be extensively used or studied.

InChI:InChI=1/C8H8ClN3/c9-5-1-2-6-7(3-5)12-8(4-10)11-6/h1-3H,4,10H2,(H,11,12)

Upstream product

• 712275-17-7 tert-butyl ((6-chloro-1H-benzo[d]imidazol-2-yl)methyl)carbamate 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 56-40-6 glycine 
• 4530-20-5 BOC-glycine 
• 1185297-00-0 (5-chloro-1H-1,3-benzodiazol-2-yl)methanamine dihydrochloride salt 

Downstream Products

• 712275-17-7 tert-butyl ((6-chloro-1H-benzo[d]imidazol-2-yl)methyl)carbamate 
• 713138-80-8 3-chloro-N-(5-chloro-1H-benzoimidazol-2-yl-methyl)-4-methoxycarbonyl-benzamide 

Relevant articles and documents

Synthesis and biological activity of squaramido-tethered bisbenzimidazoles as synthetic anion transporters

A series of squaramido-tethered bisbenzimidazoles were synthesized from the reaction of diethyl squarate with substituted 2-aminomethylbenzimidazoles. These conjugates exhibit moderate binding affinity toward chloride anions. They are able to facilitate the transmembrane transport of chloride anions most probably via an anion exchange process, and tend to be more active at acidic pH than at physiological pH. The viability of these conjugates toward four selected solid tumor cell lines was evaluated using an MTT assay and the results suggest that some of these conjugates exhibit moderate cytotoxicity probably in an apoptotic fashion.

Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer

Casein kinase 1δ/ε have been identified as promising therapeutic target for oncology application, including breast and brain cancer. Here, we described our continued efforts in optimization of a lead series of purine scaffold inhibitors that led to identification of two new CK1δ/ε inhibitors 17 and 28 displaying low nanomolar values in antiproliferative assays against the human MDA-MB-231 triple negative breast cancer cell line and have physical, in vitro and in vivo pharmacokinetic properties suitable for use in proof of principle animal xenograft studies against human cancers.

ANTI-INFECTIVE COMPOUNDS

The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.