27356-91-8

Usage

Chemical Structure

Cyclopropane derivative with a carboxylic acid group and a phenylmethyl substituent

Explanation

The compound is derived from cyclopropane, which is a three-carbon ring. It has a carboxylic acid group (-COOH) and a phenylmethyl group (C6H5-CH2-) attached to the cyclopropane ring.

Explanation

Due to its unique structure, 1-(phenylmethyl)-cyclopropanecarboxylic acid can be used as a building block or starting material in the synthesis of various pharmaceuticals and organic compounds.

Explanation

The structure of 1-(phenylmethyl)-cyclopropanecarboxylic acid allows it to be a versatile building block in organic synthesis, particularly in the development of new drugs and pharmaceuticals.

Explanation

The compound contains two main functional groups a carboxylic acid group, which is acidic and can form salts or esters, and a phenylmethyl group, which is an aromatic ring with a methyl group attached to it.

Explanation

The material does not provide information about the physical properties of 1-(phenylmethyl)-cyclopropanecarboxylic acid, such as melting point, boiling point, or solubility.

Explanation

The material does not provide information about the chemical properties of 1-(phenylmethyl)-cyclopropanecarboxylic acid, such as reactivity, stability, or potential reactions with other compounds.

Potential Applications

Synthesis of pharmaceuticals and other organic compounds

Use in Medicinal Chemistry Research

Development of new drugs

Building Block for Organic Synthesis

Drug discovery

Functional Groups

Carboxylic acid (-COOH) and phenylmethyl (C6H5-CH2-)

Physical Properties

Unknown (not provided in the material)

Chemical Properties

Unknown (not provided in the material)

Upstream product

• 79172-43-3 1-benzoylcyclopropanecarboxylic acid 
• 100-39-0 benzyl bromide 
• 20593-63-9 2-Benzylacrylic acid ethyl ester 
• 108546-99-2 t-butyl 1-benzylcyclopropanecarboxylate 
• 75-11-6 diiodomethane 
• 3070-71-1 methyl 2-benzylacrylate 
• 124-38-9 carbon dioxide 
• 7555-67-1 1-phenylmethylenecyclopropane 
• 141336-63-2 1-benzylcyclopropanecarbonitrile 
• 108546-70-9 2,6-di(tert-butyl)-4-methylphenyl 1-benzylcyclopropanecarboxylate 
• 1759-53-1 cyclopropanecarboxylic acid 
• 110419-17-5 lithium α-lithiocyclopropanecarboxylate 
• 27375-34-4 1-benzyl-cyclopropanecarboxylic acid ethyl ester 

Downstream Products

• 29813-25-0 (1-Benzyl-cyclopropyl)-carbamic acid ethyl ester 
• 27067-03-4 1-benzylcyclopropyl-1-amine 
• 105676-90-2 1-Benzylcyclopropancarbonylchlorid 
• 91245-63-5 1-Benzyl-N-methyl-cyclopropylamin 
• 29813-26-1 (1-Benzyl-cyclopropyl)-carbamic acid benzyl ester 
• 75-07-0 acetaldehyde 
• 27346-10-7 Benzyl-1-cyclopropandicarbonsaeure-1,2-anhydrid 
• 1448600-56-3 C₁₇H₁₈BrN 
• 1448600-35-8 C₁₇H₁₆BrNO 
• 1448600-02-9 N-((1-benzylcyclopropyl)methyl)-N-(2-bromophenyl)-1,1,1-trifluoromethanesulfonamide 
• 1448600-19-8 (1aS,7bS)-1a-benzyl-3-((trifluoromethyl)sulfonyl)-1a,2,3,7b-tetrahydro-1H-cyclopropa[c]quinoline 
• 1346641-00-6 1-benzyl-N-(4-cyano-2,3,5,6-tetrafluorophenyl)cyclopropanecarboxamide 

Relevant academic research and scientific papers

Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes

Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids.

Methods and Compositions for Selectin Inhibition

The present teachings relate to novel compounds of formula I: wherein the constituent variables are as defined herein. Compounds of the present teachings can act as antagonists of the mammalian adhesion proteins known as selecting. Methods for treating or preventing selectin-mediated disorders are provided, which include administration of these compounds in a therapeutically effective amount.

Heteroaryl-Pyrazole Derivatives as Cannabinoid CB1 Receptor Antagonists

A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The present invention also provides a method for preparing the inventive heteroaryl-pyrasole compounds or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.

Solvent and ligand partition reaction pathways in nickel-mediated carboxylation of methylenecyclopropanes

Methylenecyclopropanes are carboxylated with gaseous carbon dioxide in the presence of a stoichiometric amount of a nickel complex; the reaction pathways are significantly influenced by the reaction solvent and the amine ligand. The Royal Society of Chemi

Generation and Reactions of Lithiated tert-Butyl and 2,6-Di(tert-butyl)-4-methylphenyl Cyclopropanecarboxylates

tert-Butyl and 2,6-di(tert-butyl)-4-methylphenyl (BHT) cyclopropanecarboxylates (4, 6, 24, 25) are lithiated with LiN(i-Pr)2 and t-BuLi, respectively.Reactions with alkyl halides, aldehydes, acyl chlorides, and heteroelectrophiles give α-substituted BHT esters which can be cleaved (t-BuOK/H2O/THF) to the corresponding carboxylic acids or reduced (LiAlH4/THF) to the cyclopropanemethanols.

Dimerization of Cyclopropanecarboxylic Acid Dianion and Thermal Decarboxylative Rearrangement of the Dimer to 2-Cyclopropyl-4,5-dihydrofuran

The dianion of cyclopropanecarboxylic acid (2) reacted with alkyl halides and deuterated water at temperatures below 0 deg C; however, self-condensation to the β-keto acid 3 was the only observed product at elevated temperatures.This observation contrasts the self-condensation of the ethyl ester where a trimeric diester alcohol is the product.Attempted mixed condensations of the dianion 2 and carboxylic acids without acidic α-protons did not proceed as well, 3 being the major product.Thermal decarboxylation of 3 did not yield the expected dicyclopropyl ketone; rather , a facile rearrangement in a sealed tube at 120 deg C occured, giving rise to 2-cyclopropyl-4,5-dihydrofuran.This "vinyl-cyclopropyl" type rearrangement does not occur through dicyclopropyl ketone or its enolate.