27361-25-7

Upstream product

• 3471-13-4 dimedone 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 290-87-9 1,3,5-Triazine 
• 33419-22-6 3-amino-5,5-dimethyl-cyclohex-2-enone; hydrochloride 
• 3357-16-2 5,5-dimethyl-3-(1-pyrrolidinyl)-2-cyclohexen-1-one 
• 6294-83-3 [1,3,5]triazine; hydrochloride 
• 136203-55-9 9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione 
• 1152641-82-1 3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8-octahydroacridine-1,8-dione 10-oxide 
• 126-81-8 dimedone 
• 67-68-5 dimethyl sulfoxide 
• 24922-02-9 Ethyl 3-cyclopropyl-3-oxopropionate 
• 30414-53-0 methyl propanoyl acetate 
• 1118-84-9 allyl acetoacetate 
• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

1,2,3,4,5,6,7,8-Octahydro-3,3,6,6-tetramethylacridine-1,8-dione

In the title compound, C17H21NO2, the central pyridine ring is almost planar and the outer rings are half-chairs. The O atoms of the keto groups deviate significantly from the mean plane passing through their corresponding rings. The molecule contains a pseudo-mirror plane which passes through the central N and C atoms and the molecule is slightly folded along an axis passing through the same atoms. The dihedral angle between the outer rings is 6.5 (2)°. The packing is stabilized by an intermolecular C-H...O hydrogen bond.

Synthesis of pyridine derivatives by the three-component condensation of a β-dicarbonyl compound, β-enaminocarbonyl compound, and ethyl orthoformate

The major products of the three-component condensation of a β-dicarbonyl compound, β-enaminocarbonyl compound, and ethyl orthoformate are pyridine derivatives. The reaction of 1,3-cyclohexanedione or dimedone, the enamino ketones obtained from these diones, and ethyl orthoformate gives octahydroacridinediones, while the reaction of dimedone, ethyl β-aminocrotonate, and ethyl orthoformate gives a tetrahydroquinoline derivative. The structures of the minor products were established in some cases. The reduction of 3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8-octahydro-1,8-acridinedione by LiAlH4 proceeds with retention of the pyridine ring and leads to the corresponding octahydroacridinediol. 1999 KluwerAcademic/Plenum Publishers.

Photooxidation of acridine(1,8)dione dyes: Flash photolysis investigation of the mechanistic details

Photolysis of the acridinedione dyes leads to the formation of different products depending on the substitutents. The cationic radical and the solvated electron are the primary photoproducts. Flash photolysis studies show that the solvated electron subsequently reacts with the ground state molecule to give the anion radical. The enolic form of the cation radical is also observed as an intermediate. The anionic radical and enolic form of the cation radical absorb at around 480 and 550 nm respectively. Subsequently these radicals result in ketyl and carbon-centered radicals respectively. The carbon-centered radical absorbs at 650 nm.

Method for synthesizing pyridine and derivatives thereof by catalyzing Hanss ester 1, 4-dihydropyridine compound through titanocene dichloride

The invention discloses a method for synthesizing pyridine and derivatives thereof by catalyzing a Hass ester 1, 4-dihydropyridine compound through titanocene dichloride, the dihydropyridine structure of the Hass ester 1, 4-dihydropyridine compound has a certain aromatic ring driving force and is easily oxidized into a pyridine structure, and the the Hass ester 1, 4- dihydropyridine and the derivative thereof are subjected to oxidative conversion to generate the pyridine and the derivative thereof by taking titanocene dichloride as a catalyst, so that a simple way for preparing the pyridine and the derivative thereof is provided. The method is mild in reaction condition, simple to operate, short in reaction time, single in reaction product and high in atom economy, and only the product needs to be subjected to simple column chromatography separation after the reaction is finished. The Hanss ester 1, 4-dihydropyridine and the derivative thereof obtained by the invention have wide biological activity and medicinal value.

One-Pot Synthesis of Hantzsch Pyridines via NH4I Promoted Condensation of 1,3-Dicarbonyl Compounds with DMSO and NH4OAc

A one-pot synthesis of Hantzsch pyridines was achieved through NH4I-promoted condensation of 1,3-dicarbonyl compounds with DMSO and NH4OAc, in which the C4 of the pyridine rings was derived from DMSO and the nitrogen atom resulted from NH4OAc and NH4I. The target product could be obtained in moderate to excellent yields.

Synthesis and transformations of new 1,2,3,4,5,6,7,8,9,10- decahydroacridine-1,8-dione derivatives

Reactions of cyclohexane-1,3-diones with amines and aldehydes led to the formation of 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-diones containing alkylaryl, aryl, and hydroxy substituents in position 10. Transformations of 10-hydroxy-1,2,3,4,5,6,7,8,9,10

Efficient synthesis of quinazolinones as intermediates of CNS agents via inverse-electron demand Diels-Alder reaction

Enaminones undergo inverse electron demand Diels-Alder reaction with 1,3,5-triazine, allowing access to functionalised quinazolinones as intermediates in the synthesis of CNS agents. This reaction is highly dependent of the solvent: 1,3,5-triazine undergo

Synthesis of hydro-bisbenzo[1,2-a; 1′ 2′-j]acridines

Hexahydroacridinediones 1,5-7 are oxidised to tetrahydroacridinediones 2,8-10 by active MnO2 in chloroform. Formylation of tetrahydroacridinediones, followed by Michael addition with MVK and cyclisation furnishes the hydrobisbenzoacridines 18-20.