274-85-1

Usage

Uses

Used in Chemical Synthesis:
1,7,9-Triazabicyclo[4.3.0]nona-2,4,6,8-tetraene is used as a key reactant in the synthesis of various complex organic compounds, particularly in the formation of triazoloquinoline derivatives. Its unique structure allows for the creation of novel molecules with potential applications in different fields.
Used in Pharmaceutical Industry:
1,7,9-Triazabicyclo[4.3.0]nona-2,4,6,8-tetraene is used as an intermediate in the development of new pharmaceutical compounds. Its reactivity and structural diversity make it a valuable building block for designing and synthesizing novel drugs with improved therapeutic properties.
Used in Research and Development:
In the field of research and development, 1,7,9-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene serves as a versatile compound for exploring new reaction pathways and understanding the fundamental chemistry of heterocyclic systems. Its unique properties can lead to the discovery of new synthetic methods and applications in various industries.

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 1677, 1973 DOI: 10.1016/S0040-4039(01)96026-5

InChI:InChI=1/C6H5N3/c1-2-4-9-6(3-1)7-5-8-9/h1-5H

Upstream product

• 64-18-6 formic acid 
• 72647-21-3 1-amino-2-hydroxyimino-1,2-dihydropyridine 
• 69512-30-7 N'-hydroxy-N-(pyridin-2-yl)formimidamide 
• 33842-49-8 ethyl N-(pyridin-2-yl)formimidate 
• 109-09-1 2-chloropyridine 
• 1640-73-9 N-pyridyl-2'-thioformamide 
• 504-29-0 2-aminopyridine 

Downstream Products

• 108361-92-8 2-(2-imino-5-phenyl-2,3-dihydrooxazol-3-yl)pyridine 
• 870784-29-5 tert-butyl [(1S,2S)-1-{[3,3-difluoropyrrolidin-1-yl]carbonyl}-2-(4-[1,2,4]triazolo[1,5-a]pyridin-5-ylcyclohex-3-yl)propyl]carbamate 
• 4931-27-5 5-methyl[1,2,4]triazolo[1,5-a]pyridine 
• 143307-82-8 [1,2,4]triazolo[1,5-a]pyridine-5-carbaldehyde 
• 143307-80-6 α-<3-(trifluoromethyl)phenyl><1,2,4>triazolo<1,5-a>pyridine-5-methanol 
• 143329-58-2 5-bromo<1,2,4>triazolo<1,5-a>pyridine 

Relevant academic research and scientific papers

A New Synthesis of the s-Triazolopyridine Ring System

A novel and efficient synthesis of s-triazolopyridines was elaborated by reacting 1,2-diaminopyridinium salts with aldehydes. - Keywords: Ring closure; Triazoles, fused; Dipolar cycloaddition

New method for the general synthesis of [1,2,4]triazolo[1,5-a]pyridines

[1,2,4]Triazolo[1,5-a]pyridines without substituants on the 2-position have been prepared from 2-aminopyridines by cyclization of N-(pyrid-2-yl) formamidoximes with trifluoroacetic anhydride. Triazoles substituted at any position on the pyridine ring may be prepared in good yields and under mild reaction conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

FUNCTIONALIZED ENAMINES IN THE SYNTHESIS OF SOME HETEROCYCLIC COMPOUNDS

Esters of 3-amino-2-cyanoacrylate and analogous compounds were used as starting material for pyridines which were obtained via the corresponding amidines.On the other hand, from ethyl 5-aminoisoxazole-4-carboxylate or 5-amino-4-cyanoisoxazole in a similar reaction sequence a pyrimidine derivative could be prepared.

SYNTHESES AND TRANSFORMATIONS OF SOME HETEROCYCLIC HYDROXYLAMINES

Syntheses of some hydroxylaminoazines, their quaternized derivatives or N-oxides and N-amino compounds are described.Several transformations of these compounds and cyclization reactions are presented.