2741-13-1

Usage

Uses

Used in Organic Synthesis:
1,1-dimethyl-3-(4-methylphenyl)thiourea is used as a reagent in organic synthesis for the preparation of various organic compounds.
Used in Pharmaceutical Industry:
1,1-dimethyl-3-(4-methylphenyl)thiourea is used as a starting material in the formulation of pharmaceuticals due to its potential antimicrobial, antifungal, and antitumor activities.
Used in Dye Industry:
1,1-dimethyl-3-(4-methylphenyl)thiourea is used in the formulation of dyes due to its chemical properties.
Used in Research and Development:
1,1-dimethyl-3-(4-methylphenyl)thiourea is of interest for further research and development in various fields, including pharmaceuticals, dyes, and other industries, due to its potential applications and properties.

Upstream product

• 124-40-3 dimethyl amine 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 106-49-0 p-toluidine 
• 16906-70-0 phenyl N,N-dimethyl dithiocarbamate 
• 137-26-8 Thiram 

Downstream Products

• 75104-97-1 N,N,6-trimethylbenzo[d]thiazol-2-amine 
• 74376-27-5 ethyl 5-methyl-2-p-tolylimino-1,3-oxathiole-4-carboxylate 
• 20044-34-2 ethyl 2-p-tolylimino-4-methyl-Δ⁴-thiazoline-5-carboxylate 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 621-01-2 N,N'-Bis(p-tolyl)thiourea 
• 39192-94-4 N-(p-methylphenyl)-p-methoxybenzamide 
• 6917-08-4 N-(4-methylphenyl)-4-nitrobenzamide 
• 2447-95-2 4-chloro-N-(4-tolyl)benzamide 
• 6876-66-0 4,4'-dimethylbenzanilide 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 1329429-63-1 1,1-dimethyl-2-phenyl-3-p-tolyl-isothiourea 
• 1329429-61-9 N,N-dimethyl-2-phenylsulfanyl-N'-p-tolyl-benzamidine 
• 506-59-2 N,N-dimethylammonium chloride 
• 75592-13-1 C₁₁H₁₄N₄ 

Relevant academic research and scientific papers

Method for preparing aryl isothiourea

The invention discloses a method for preparing aryl isothiourea, wherein hydride is suspended in a solvent, and thiourea is sequentially added. O diiodo benzene followed by reaction to prepare aryl isothiosemicarbazone. The isothiourea structure is widely

Facile synthesis of substituted arylthioureas in the presence of sodium hydride

A series of 11 1,1-dimethyl-3-aryl-thioureas were synthesised in good yields (70-92%) by reacting arylamines with S-aryl-N,Ndimethylthiocarbamate in DMSO in the presence of NaH at 90 °C. It is noteworthy that this method can also be used for arylamines containing a halogen atom at the ortho position.

Insertion of arynes into thioureas: A new amidine synthesis

Arynes, generated from trimethylsilyl phenyltriflate precursors, have been found to react with thioureas via a formal π-insertion into the C=S bond. The reaction contrasts with that of ureas, which proceeds via benzyne σ-insertion into the C-N bond, and r

Use of tetramethylthiuram disulfide in synthesis of nitrogen-containing heterocyclic compounds

We have developed a method for synthesis of aryl isothiocyanates by means of thiocarbamoylation of aromatic amines by tetramethylthiuram disulfide followed by degradation of the intermediate N(1)-aryl-N,N- dimethylthiourea by concentrated HCl. We have shown that thiocarbamoylation of 4-amino-5-ethyl-4H-1,2,4-triazole-3-thiol occurs at the 2 position of the triazole ring, while thiocarbamoylation of 4-amino-3-methyl-6-phenyl-4,5- dihydro-1,2,4-triazin-5-one leads to the dihetaryl-substituted thiourea. We consider the possibility of using N(1)-aryl-N,N-dimethylthioureas as analogs of isothiocyanates in reactions with N-nucleophiles. 2005 Springer Science+Business Media, Inc.

Reaction of 1,4,2-Dithiazolium Salts with Amino Compounds

Systematic studies on the behavior of 1,4,2-dithiazolium cations (1) toward various amino compounds (ammonia, aliphatic and aromatic amines, hydrazine, semicarbazide, thiosemicarbazide derivatives, etc.) were performed.The reaction pathway could be classified into three types depending on possibile three fission modes of the initially-formed adduct.The main products were 5-imino-1,4,2-dithiazole, thiourea, and 1,3,4-thiadiazole derivatives, through the three different pathways, respectively.In order to clarify the factors controlling the reaction courses, the reactions of 1 with p-substituted aniline derivatives were carried out under systematically varying conditions.The strength of bases and the polaritiy of solvents had clear influence on the reactivity.The reaction mechanism is also discussed.