27472-21-5

Usage

Uses

Used in Pharmaceutical Research and Development:
3,4-Diethoxyphenylacetonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and improve existing ones. Its aromatic nature and reactivity make it a preferred choice in the creation of novel medicinal compounds.
Used in Organic Synthesis:
In the realm of organic chemistry, 3,4-Diethoxyphenylacetonitrile is utilized as a versatile reagent, playing a crucial role in the synthesis of a wide range of organic molecules. Its unique structure allows for various chemical reactions, contributing to the creation of complex organic compounds.
Used in Manufacturing of Chemical Products:
3,4-Diethoxyphenylacetonitrile is employed as a building block in the manufacturing process of a diverse array of chemical products. Its application extends beyond pharmaceuticals, finding use in the production of various consumer goods, industrial chemicals, and specialty products, highlighting its broad utility in the chemical industry.

InChI:InChI=1/C12H15NO2/c1-3-14-11-6-5-10(7-8-13)9-12(11)15-4-2/h5-6,9H,3-4,7H2,1-2H3

Upstream product

• 27472-20-4 1,2-diethoxy-4-chloromethyl-benzene 
• 143-33-9 sodium cyanide 
• 83459-29-4 (3,4-diethoxyphenyl)methanol 
• 2029-94-9 3,4-diethoxybenzaldehyde 
• 74-96-4 ethyl bromide 
• 1126-62-1 (3,4-dihydroxy-phenyl)-acetonitrile 
• 5409-31-4 3,4-diethoxybenzoic acid 
• 151-50-8 potassium cyanide 

Downstream Products

• 857564-02-4 3',4'-diethoxy-2,4-dihydroxy-6-methoxy-deoxybenzoin 
• 153742-17-7 methyl 2-cyano-2-(3,4-diethoxyphenyl) acetate 
• 857564-00-2 2,3',4'-triethoxy-4,6-dihydroxy-deoxybenzoin 
• 1425539-79-2 11-{4-[(Z)-2-cyano-2-(3,4-dimethoxyphenyl)ethenyl]-2-methoxyphenoxy}undecyl 2-methylacrylate 
• 1439376-28-9 2-(3,4-diethoxyphenyl)propanenitrile 
• 1439376-30-3 (Z)-2-(3,4-diethoxyphenyl)-N'-hydroxyacetimidamide 
• 113915-28-9 C₁₂H₁₃F₆NO₂ 
• 1439376-29-0 2-(3,4-bis(2,2,2-trifluoroethoxy)phenyl)acetonitrile 
• 1126-62-1 (3,4-dihydroxy-phenyl)-acetonitrile 
• 313367-04-3 C₁₃H₂₁NO₂ 
• 698993-84-9 2-(3',4'-diethoxybenzyl)-4,4-diphenyl-3,4-dihydroquinazoline 
• 1425934-26-4 2-(3,4-diethoxybenzyl)-4,4-diphenyl-3,4-dihydroquinazolinium perchlorate 
• 1044502-66-0 cis-bis[(3,4-diethoxy-phenyl)acetonitrile]dichloroplatinum (II) 
• 102663-69-4 6,7-diethoxy-1-veratryl-isoquinoline 

Relevant academic research and scientific papers

New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure–activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3(trifluoromethyl)benzamide possessed good physicochemical properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50 (NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50 (K1 ) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved.

Photoreactive compounds

The present invention relates to photoreactive compounds that are particularly useful in materials for the alignment of liquid crystals.

PHOTOREACTIVE COMPOUNDS

The present invention relates to photoreactive compounds that are particularly useful in materials for the alignment of liquid crystals.

Enzymes in organic synthesis 51. Probing the dimensions of the large hydrophobic pocket of the active site of pig liver esterase

The dimensions of the large hydrophobic pocket (H(L)) of the active site model of pig liver esterase (PLE) were probed using a series of aliphatic and phenylic malonates. Results from the hydrolyses of these new unnatural substrates permitted the extension of the H(L) pocket to give the new dimensions of 6.2 x 2.3 x 3.9 A for a total volume of ~56 A3.