275-02-5

Usage

Uses

Used in Pharmaceutical Industry:
1,2,4-Triazolo[1,5-a]pyrimidine is used as a key building block in the synthesis of various pharmaceuticals and biologically active molecules. Its unique structure and properties make it a valuable component in the development of new drugs with potential therapeutic applications.
1. As an Anti-inflammatory Agent:
1,2,4-Triazolo[1,5-a]pyrimidine is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain associated with various conditions.
2. As an Analgesic:
1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE is utilized as an analgesic to provide relief from moderate to severe pain by interacting with pain receptors and reducing the sensation of discomfort.
3. As an Antitumor Agent:
1,2,4-Triazolo[1,5-a]pyrimidine is employed as an antitumor agent, targeting cancer cells and inhibiting their growth and proliferation. Its potential to modulate various signaling pathways involved in tumor development and progression makes it a promising candidate for cancer therapy.
4. As an Antimicrobial Agent:
1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE is used as an antimicrobial agent to combat bacterial infections by disrupting essential cellular processes and inhibiting the growth of pathogenic bacteria.
5. As an Antiviral Agent:
1,2,4-Triazolo[1,5-a]pyrimidine is utilized as an antiviral agent to prevent the replication and spread of viruses, offering potential therapeutic benefits in the treatment of viral infections.

InChI:InChI=1/C5H4N4/c1-2-6-5-7-4-8-9(5)3-1/h1-4H

Upstream product

• 7504-94-1 2-pyrimidinylhydrazine 
• 64-18-6 formic acid 
• 274-98-6 [1,2,4]triazolo[4,3-a]pyrimidine 
• 52341-91-0 7-chloro-[1,2,4]triazolo[1,5-a]pyrimidine 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 764-63-6 (E)-3-ethoxyacrylaldehyde 
• 927-63-9 (E)-3-(dimethylamino)acrolein 
• 31592-08-2 4,7-dihydro-1,2,4-triazolo<1,5-a>pyrimidin-7-one 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 542-78-9 Malondialdehyde 
• 61-82-5 3-amino-1,2,4-triazole 
• 927-63-9 3-dimethylaminoacrolein 

Downstream Products

• 39573-72-3 7-phenyl-1,2,4-triazolo<1,5-a>pyrimidine 
• 160290-42-6 7-(4-chlorophenyl)-1,2,4-triazolo<1,5-a>pyrimidine 

Relevant academic research and scientific papers

Two different compounds formed from copper(II) tetrafluoridoborate and [1,2,4]triazolo[1,5-a]pyrimidine. Synthesis, spectroscopy and single-crystal structures

Two coordination compounds copper(II) with tetrafluoridoborate as the anion and [1,2,4]triazolo[1,5-a] pyrimidine (abbreviated as tp) as the ligand are presented, together with their crystal structure and spectroscopic properties. A light blue compound [Cu(tp)4 H2O)2](BF 4)2 (CH3OH) (1) with a tetragonal chromophore and a dark blue compound [Cu(tp)5](BF4)2(CH3OH) (2) are formed from the same batch. Compound (2) has a quite unusual geometry for Cu(II) with just 5 tp ligands, homoleptically coordinated to the metal ion. Both compounds show interesting hydrogenbond interactions in the solid state, where coordinated water is intramolecularly bound to non-coordinated N atoms of tp (in 1), and methanol is attached to the anion (in 2). The Author(s) 2010.

Synthesis of New [1,2,4]Triazolo[1,5-a]pyrimidine Derivatives: Reactivity of 3-Amino[1,2,4]triazole towards Enaminonitriles and Enaminones

A diversity of new 7-substituted[1,2,4]triazolo[1,5-a]pyrimidine and 6-substituted[1,2,4]triazolo[1,5-a]pyrimidine-7-amine derivatives has been synthesized via reaction of 3-amino-[1,2,4]triazole with enaminonitriles and enaminones. The regio orientation and the structure of the products were confirmed by spectral and analytical data and synthesis via an alternative route. The procedure proved to be simple, efficient, and high yielding, and diversities of [1,2,4]triazolo[1,5-a]pyrimidines were obtained.

Differentiation between [1,2,4]triazolo[1,5-a] pyrimidine and [1,2,4]triazolo[4,3-a]- Pyrimidine regioisomers by 1H-15N HMBC experiments

The condensation of malonoaldehyde derivatives with either a 3-amino-[1,2,4]-triazole or a 3,5-diamino-[1,2,4]-triazole precursor was studied. In agreement with previous reports, two different bicycles, namely, bearing the regioisomeric [1,2,4]triazolo[1,

Studies with functionally substituted enamines: The reactivity of enaminals and enamino esters toward naphthoquinone, hydrazonoyl halides, aminoazoles and hippuric acid

Whereas enamines 1a,b react with naphthoquinone (2) to yield the naphthofuranals 5a,b, enamine ester 1c react with 2 to yield benzoindole derivatives 7. Enamine 1b reacts with hydrazonoyl halides 8 to yield 3,4-disubstituted pyrazoles 12. On the other hand, the enaminal 1a failed to react with 8, while enamine ester 1c afforded hydrazone 16 on treatment with 8. The enamino ester 1b afforded triethyl 1,3,5-benzenetricarboxylates on refluxing in acetic acid. Georg Thieme Verlag Stuttgart.