2755-72-8Relevant academic research and scientific papers
Synthesis and structural studies of isomeric Δ2- pyrazolines
Ingle,Doshi,Raut
experimental part, p. 1517 - 1520 (2011/10/13)
1-(2′-Thienyl)-3-(4″-dimethylamino phenyl)-2-propen-1-one(la-e) react with hydrazine hydrochloride in DMF medium to give isomeric 1-H pyrazolines (lla-e), react with phenyl hydrazine hydrochloride in DMF medium to give isomeric 1 -phenyl pyrazolines (Illa
Synthesis of and pharmacological studies on the antidepressant and anticonvulsant activities of some 1,3,5-trisubstituted pyrazolines
Ruhoglu, Ozan,Oezdemir, Zuhal,Calis, Uensal,Guemuesel, Buelent,Bilgin, Abdullah Altan
, p. 431 - 436 (2007/10/03)
Eighteen 1-phenyl-, 1-thiocarbamoyl- and 1-N-substitutedthiocarbamoyl-3- phenyl-5-heteroaryl-2-pyrazoline derivatives were synthesized and tested for their antidepressant and anticonvulsant activities. Their chemical structures were proved by spectral and microanalysis. The antidepressant activities of the compounds were investigated by the "forced swimming test". Results showed that compounds II-a,b,c, III-1b,1c,4a showed activities equivalent to or higher than pargyline hydrochloride (CAS 306-07-0) and tranylcypromine sulfate (CAS 13492-01-8) that were used as reference antidepressant drugs. Anticonvulsant activities of the compounds were determined by maximal electroshock seizure (MES), subcutaneous metrazol (ScMet.) and rotarod toxicity tests in mice according to the phase I tests of the Antiepileptic Drug Development programme. Compounds I-a, II-a,b,c, III-1b,2a,2c were found protective against MES and III-1b,1c,2a,2c were found protective against ScMet. ECV · Editio Cantor Verlag.
Heterocycles. 3. Synthesis and Spectral Data of Some 2-Pyrazolines
El-Rayyes, Nizar R.,Hovakeemian, George H.,Hmoud, Hayat S.
, p. 225 - 229 (2007/10/02)
The reaction of 1,3-diaryl-2-propen-1-ones (Ia-o) with hydrazine and methyl- and phenylhydrazine produced different substituted 2-pyrazolines (III).The structures of these products were evident from their chemical and spectroscopic analysis.
Thienyl acrylamides and thienyl pyrazolines as potential schistosomicidal agents
El Kerdawy,Samour,El Agamey
, p. 76 - 77 (2007/10/08)
α Thienyl N substituted acrylamides that possess analogous structures to known schistosomicidal agents were synthesized. Two chalcones were prepared by condensing α thiophenealdehyde and acetophenone or its o hydroxy derivative. Cyclization of the chalcon
