276249-18-4

Usage

Uses

Used in Pharmaceutical Research:
6-CHLORO-3,5-DIOXO HEXANIC ACID, 1,1-DIMETHYL ETHYL ESTER is used as a research chemical for its ability to inhibit a specific enzyme, which is crucial in the study of biochemical processes and the development of new drugs targeting those enzymes.
Used in Chemical Synthesis:
In the chemical industry, 6-CHLORO-3,5-DIOXO HEXANIC ACID, 1,1-DIMETHYL ETHYL ESTER serves as a building block in the synthesis of other compounds, contributing to the creation of novel pharmaceuticals and chemical products.
Used in Environmental and Health Regulations:
Due to its potential environmental and human health hazards, 6-CHLORO-3,5-DIOXO HEXANIC ACID, 1,1-DIMETHYL ETHYL ESTER is subject to strict regulations and guidelines, ensuring its safe handling, storage, and disposal within various industries.

InChI:InChI=1/C10H15ClO4/c1-10(2,3)15-9(14)5-7(12)4-8(13)6-11/h4-6H2,1-3H3

Upstream product

• 96-34-4 methyl chloroacetate 
• 1401896-78-3 C₁₀H₁₁ClO₆ 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 154026-93-4 1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate 
• 135999-61-0 (S)-6-chloromethyl-5,6-dihydropyran-2-one 
• 154026-92-3 Tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate 
• 404958-08-3 tert-butyl (R)-6-chloro-5-hydroxy-3-oxohexanoate 

Relevant academic research and scientific papers

PREPARATION OF 3,5-DIOXO HEXANOATE ESTER IN TWO STEPS

The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5- dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl (4R,6S)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate(BHA), Rosuvastatin and Atorvastatin.

Highly regio- and enantioselective reduction of 3,5-dioxocarboxylates

Only the keto group in position C-5 is reduced in the enzymatic reduction of 3,5-dioxocarboxylates by the alcohol dehydrogenase of Lactobacillusbrevis (LBADH; see scheme). The strategy of nature for manipulating β-keto metabolites inspired the development of a chemoenzymatic approach to virtually enantiopure 3,5-dihydroxycarboxylate building blocks. The crucial enzymatic step can be performed on an attractively large scale.