27684-79-3

Usage

InChI:InChI=1/C12H20N2O2/c1-9(2)14-7-11(15)8-16-12-5-3-10(13)4-6-12/h3-6,9,11,14-15H,7-8,13H2,1-2H3

Upstream product

• 6673-35-4 practolol 
• 125228-75-3 4-nitrophenyl 2-oxiranylmethyl ether 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 111218-78-1 2-Chloro-4-<4-(3'-isopropylamino-2'-oxypropoxy)phenylamino>-6,7-dimethoxyquinazoline 
• 6673-33-2 1-(4-Ethoxycarbonylaminophenoxy)-2-hydroxy-3-isopropylaminopropan 
• 65854-89-9 1-(p-iodophenoxy)-3-isopropylamino-2-propanol 
• 175532-42-0 3-[4-(amino)phenoxy]-11-N-(tertbutoxycarbonyl)isopropylaminopropan-2-ol 
• 265669-10-1 3-[4-(prop-2-ynyloxycarbonylamino)phenoxy]-1-(N-tert-butoxycarbonyl)isopropylaminopropan-2-ol 
• 265669-12-3 3-[4-(3-iodoprop-2-enyloxycarbonylamino)phenoxy]-1-N-(tert-butoxycarbonyl)isopropylaminopropan-2-ol 
• 280580-27-0 4-Anilino-5-chloro-2-{4-[2-hydroxy-3-(isopropylamino)propoxy]anilino}pyrimidine 
• 72224-51-2 N-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-3-(4-phenyl-piperazin-1-yl)-propionamide 

Relevant academic research and scientific papers

2,4-DIAMINO PYRIMIDINE COMPOUNDS HAVING ANTI-CELL PROLIFERATIVE ACTIVITY

A pyrimidine derivative of formula (I) wherein, for example, R1 is hydrogen, (1-6C)alkyl, (3-5C)alkenyl or (3-5C)alkynyl; Q1 and Q2 are independently selected from phenyl, naphthyl, indanyl and 1,2,3,4-tetrahydronaphthyl; and one or both of Q1 and Q2 bear

Synthesis of potentially β-blocking practolol derivatives: (E + Z)-3- [4-(3-iodoprop-2-enyloxycarbonylamino)phenoxy]-1-(isopropylamino)propan-2-ol

The iodinatied carbamates 3 (E + Z), with potential β-blocking properties, were synthesized. The first route chosen, from 4-aminophenol and the chloroformate 7, had to be abandoned because of the formation of the oxazolidinone 10 during the epoxidation step. The aminoalcohol 17 prepared from the practolol 1 finally gave the target compounds by condensation with the iodoallylic chloroformates 8 (E + Z). The secondary Boc-protected amine function was regenerated without removing the carbamate function situated in the p-postion, by using mild reaction conditions (1 N HCl).

The Synthesis and Potassium Channel Blocking Activity of Some (4-Methanesulfonamidophenoxy)propanolamines as Potential Class III Antiarrhythmic Agents

The synthesis of 22 (4-methanesulfonamidophenoxy)propanolamines and their testing on isolated guinea pig cardiac myocytes, on isolated preparations from guinea pig atria, and on rat blood pressure are described.Secondary amines in the series (11a-f) showe