2775-38-4

Usage

Chemical Properties

Yellow powder

InChI:InChI=1/C7H5Cl2NS/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H2,10,11)

Upstream product

• 6574-98-7 2,4-dichlorobenzylnitrile 
• 2447-79-2 2,4-dichlorobenzamide 
• 56843-28-8 2,4-dichlorobenzaldoxime 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 23822-12-0 [2-(2,4-dichloro-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid 
• 648889-07-0 2-(2,4-dichloro-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 97992-67-1 4-chloromethyl-2-(2,4-dichlorophenyl)thiazole 
• 1236827-22-7 3,5-bis(2,4-dichlorophenyl)[1,2,4]thiadiazole^?  
• 7047-06-5 5-(2,4-dichloro-phenyl)-[1,2,4]dithiazole-3-thione 
• 1314243-53-2 C₁₃H₉Cl₂NOS 
• 82891-85-8 2-(2,4-dichlorophenyl)-4,5-dihydrooxazole 
• 1185155-89-8 ethyl 2-(2,4-dichlorophenyl)-1,3-thiazole-4-carboxylate 
• 1306101-93-8 ethyl 4-(2,4-dichlorophenyl)thiazole-2-carboxylate 
• 472804-18-5 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis, Activity, and Docking Study of Novel Phenylthiazole-Carboxamido Acid Derivatives as FFA2 Agonists

Free fatty acid receptor 2 (FFA2), also known as GPR43, is activated by short-chain fatty acids (SCFAs) that are mainly produced by the gut microbiota through the fermentation of undigested carbohydrates and dietary fibers. FFA2 currently appears to be a

Metal-free, one-pot oxidative conversion of aldehydes to primary thioamides in aqueous media

One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

A novel process for the synthesis of 3,5-diaryl-1,2,4-thiadiazoles from aryl nitriles

A novel and efficient process for the synthesis of 3,5-diaryl-1,2,4- thiadiazoles from aryl nitriles in 1-butyl-3-methylimidazolium bromide promoted by (NH4)2S and TCT-DMSO is described.

Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets

Chemoprevention is an approach to decrease cancer morbidity and mortality through inhibition of carcinogenesis and prevention of disease progression. Although the trans stilbene derivative resveratrol has chemopreventive properties, its action is compromised by weak non-specific effects on many biological targets. Replacement of the stilbene ethylenic bridge of resveratrol with a 1,2,4-thiadiazole heterocycle and modification of the substituents on the two aromatic rings afforded potential chemopreventive agents with enhanced potencies and selectivities when evaluated as inhibitors of aromatase and NF-κB and inducers of quinone reductase 1 (QR1).

A thiophosphoryl chloride assisted transformation of arylaldoximes to thioamides

Primary benzothioamides were accessed from benzaldoximes (benzaldehyde oximes) via benzonitriles in a sequential tandem approach utilizing thiophosphoryl chloride as a dehydrating and thionating agent. Georg Thieme Verlag Stuttgart New York.

Efficient and green protocol for the synthesis of thioamides in C 6 (mim)2Cl2 as a dicationic ionic liquid

A simple, efficient, facile and eco-friendly process for the synthesis of thioamides from nitriles using 1,6-bis(3methylimidazolium-1-yl)hexane chloride [C6(mim)2Cl2] as a dicationic ionic liquid (DIL) was developed. The ionic liquid was easily separated from the reaction mixture and was recycled at least four times without any loss of its activity.

TiCl3OTf-[bmim]Br: a novel and efficient catalyst system for chemoselective one-pot synthesis of thioamides from arylaldoximes

The combination of TiCl3OTf with 1-butyl-3-methylimidazolium bromide is found to be an efficient and novel catalytic system for chemoselective one-pot transformation of arylaldoximes to their corresponding thioamides in high to excellent yields.

Phosphorus pentasulfide: A mild and versatile reagent for the preparation of thioamides from nitriles

A simple, efficient, and new method has been developed for the synthesis of thioamides from nitriles. The reaction of a variety of aromatic and aliphatic nitriles in the presence of phosphorus pentasulfide afforded the corresponding thioamides in high yields. This method is easy, rapid, and high-yielding for the synthesis of thioamides from nitriles. Georg Thieme Verlag Stuttgart.

ARYL PIPERIDINE DERIVATIVES AND USE THEREOF TO REDUCE ELEVATED LEVELS OF LDL-CHOLESTEROL

This invention relates to novel compounds which up-regulate LDL receptor (LDL-r) expression and to processes for their preparation, pharmaceutical compositions containing them and their medical use. More particularly, this invention relates to novel aromatic piperidines and their use in therapy.