2775-86-2

Usage

Uses

Used in Pharmaceutical Industry:
2,4(1H,3H)-Pyrimidinedione, 1-benzoylis used as a precursor compound for the synthesis of various pharmaceuticals, including barbiturates and some antineoplastic agents. Its derivatives exhibit sedative, hypnotic, and anticonvulsant properties, making it a valuable component in the development of medications for treating insomnia, anxiety, and seizure disorders.
Used in Medicinal Industry:
In the medicinal industry, 2,4(1H,3H)-Pyrimidinedione, 1-benzoylis utilized for its potential in the synthesis of therapeutic agents. Its derivatives have been found to possess sedative, hypnotic, and anticonvulsant properties, which contribute to the development of medications for various medical conditions, such as sleep disorders, anxiety, and epilepsy.

Upstream product

• 98-88-4 benzoyl chloride 
• 66-22-8 uracil 
• 10457-14-4 O,O'-bis-(trimethylsilyl)uracil 

Downstream Products

• 608-34-4 3-methyluracil 
• 66-22-8 uracil 
• 934816-12-3 C₃₂H₃₁FN₂O₅ 
• 869710-91-8 (3aR,4R,6aS)-4-Benzyloxymethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxole 
• 215544-47-1 1-Benzoyl-4-thiouracil 

Relevant academic research and scientific papers

New [11C]phosgene based synthesis of [11C]pyrimidines for positron emission tomography

Thymine, 5-FU, and uracil were successfully synthesized through a procedure involving a cyclocondensation of triphosgene with newly developed (α-substituted β-aminoacrylamides intermediates (1a, X= Me; 1b, X= F; 1c, X= H). The radioligands [2-11C]thymine and [2- 11C]5-fluorouracil were synthesized in high radiochemical yields in 16-17 minutes from the end of bombardment by applying the cyclocondensation method with [11C]COCl2.

Microwave-assisted synthesis of amides from various amines and benzoyl chloride under solvent-free conditions: A rapid and efficient method for selective protection of diverse amines

A number of structurally diverse amides were synthesized by reaction of the corresponding amines with benzoyl chloride under microwave irradiation. The proposed procedure ensures short reaction time, high yields, and excellent selectivity and considerably broadens the series of amines as compared to the microwave-assisted synthesis of amides directly from carboxylic acids. It can also be used for selective protection of various amines, including aromatic, aliphatic, and heterocyclic.

Microwave-promoted conversion of heterocyclic amines to corresponding amides under solvent-free conditions

An array of heterocyclic amides was synthesized efficiently by combining corresponding amines and benzoyl chloride in one-pot under microwave irradiation. The reaction times were shorter, yields were higher. What is more, the regioselectivity was excellent, which made the protocol support us an entry to selective protection of diverse amino groups.

AMIDOALKYLATION OF PYRIMIDINE BASES OF NUCLEIC ACIDS

The reaction of uracil, thymine, and cytosine with acid N-α-chloroalkylamides gave N-substituted derivatives of these compounds.Conditions for the selective amidoalkylation of pyrimidine bases in the 1 position were found.

THE BENZOYLATION OF URACIL AND THYMINE

Uracil and thymine react with benzoyl chloride in acetonitrile-pyridine solution at room temperature to give first their 1-N-benzoyl (2b and 3b) and then their 1-N,3-N-dibenzoyl derivatives (4a and 4b, respectively); the latter compounds are converted into the corresponding 3-N-benzoyl derivatives (5a and 6a) under mild conditions of basic hydrolysis.