869710-91-8Relevant academic research and scientific papers
Stereoselective Synthesis of 1′,2′- cis -Disubstituted Carbocyclic ribo -Nucleoside Analogues
Weising, Simon,Torquati, Ilaria,Meier, Chris
, p. 1264 - 1274 (2018)
Herein we disclose an efficient strategy for the convergent synthesis of 1′,2′- cis -disubstituted carbocyclic ribo -nucleoside analogues. Starting from an enantiomerically pure cyclopentenol precursor, the key step for the preparation of the highly functionalized carbocyclic building block is an asymmetric dihydroxylation. Employing different variants of the Mitsunobu protocol, the condensation with all-natural nucleobases or their precursors affords a series of ribo -configured carbocyclic 1′,2′- cis -disubstituted nucleoside analogues.
Chiral syntheses of 6′-β-fluoroaristeromycin, 6′-β-fluoro-5′-noraristeromycin and aristeromycin
Yin, Xue-Qiang,Schneller, Stewart W.
, p. 7535 - 7538 (2007/10/03)
Carbocyclic nucleosides substituted at the C-6′ position are receiving increasing attention. Chiral synthetic accessibility to the biologically promising 6′-β-fluoroaristeromycin is lacking. Its preparation and that of the 5′-nor analogue are described. A
