374633-80-4Relevant academic research and scientific papers
Synthesis and biological activities of novel β-carbolines as PDE5 inhibitors
Sui, Zhihua,Guan, Jihua,Macielag, Mark J.,Jiang, Weiqin,Qiu, Yuhong,Kraft, Patricia,Bhattacharjee, Sheela,John, T. Matthew,Craig, Elizabeth,Haynes-Johnson, Donna,Clancy, Joanna
, p. 761 - 765 (2007/10/03)
A series of N2-furoyl and N2pyrimidinyl β-carbolines was discovered to possess potent inhibitory activity against PDE5. During the synthesis we developed a tandem resin quenching protocol, which allowed us to synthesize large number
Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction
Sui, Zhihua,Guan, Jihua,Macielag, Mark J.,Jiang, Weiqin,Zhang, Suying,Qiu, Yuhong,Kraft, Patricia,Bhattacharjee, Sheela,John, T. Matthew,Haynes-Johnson, Donna,Clancy, Joanna
, p. 4094 - 4096 (2007/10/03)
A series of N-pyrimidinylpyrroloquinolones were discovered as extremely potent and selective PDE5 inhibitors. Representative compounds demonstrated in vivo efficacy in dog erectile dysfunction models and are orally bioavailable.
