27883-63-2Relevant academic research and scientific papers
A new approach to synthesis of 3,3-dialkyl-3,4-dihydroisoquinoline derivatives
Shklyaev,Yeltsov,Rozhkova,Tolstikov,Dembitsky
, p. 486 - 493 (2007/10/03)
The synthesis of 3,3-dialkyl-3,4-dihydroisoquinolines via heterocyclization in three-component reaction of an activated arene with isobutyraldehyde and nitriles is described.
Three-component synthesis of 3,4-dihydroisoquinoline derivatives
Shklyaev, Yu. V.,Nifontov, Yu. V.
, p. 844 - 849 (2007/10/03)
A simple and convenient method for the synthesis of 1-substituted 3,3-dimethyl-3,4-dihydroisoquinolines was developed. The method is based on the [2+2+2] cyclization of alkyl- or alkoxybenzenes with isobutyraldehyde and nitriles.
