279252-26-5

Basic information

• Product Name: 2-Chloro-4-(trifluoromethyl)benzyl bromide
• Synonyms: 2-Chloro-4-(trifluoromethyl)benzyl bromide;1-(bromomethyl)-2-chloro-4-(trifluoromethyl)benzene;BENZENE, 1-(BROMOMETHYL)-2-CHLORO-4-(TRIFLUOROMETHYL)-
• CAS NO: 279252-26-5
• Molecular Formula: C₈H₅BrClF₃
• Molecular Weight: 273.4775096
• Mol File: 279252-26-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-4-(trifluoromethyl)benzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-(trifluoromethyl)benzyl bromide(279252-26-5)
• EPA Substance Registry System: 2-Chloro-4-(trifluoromethyl)benzyl bromide(279252-26-5)

Safety Data

• Hazardous Substances Data: 279252-26-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-(trifluoromethyl)benzyl bromide is a highly reactive and potentially hazardous chemical compound. It is classified as an alkyl bromide and contains a chloro and trifluoromethyl group attached to a benzene ring. This chemical is commonly used in organic synthesis and as a reagent for introducing the benzyl bromide functional group into various organic molecules. However, it is important to handle this compound with caution due to its potential to cause skin, eye, and respiratory irritation, as well as its flammability and reactivity with water. Proper safety protocols and protective equipment should be used when working with 2-Chloro-4-(trifluoromethyl)benzyl bromide to minimize the risk of exposure and accidents.

Upstream product

• 56456-51-0 (2-chloro-4-(trifluoromethyl)phenyl)methanol 
• 135049-84-2 4-bromomethyl-3-chloroiodobenzene 
• 558-13-4 carbon tetrabromide 
• 74483-47-9 2-Chloro-4-(trifluoromethyl)toluene 

Downstream Products

• 888739-48-8 ethyl 3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}propanoate 
• 219768-33-9 3-(2-Chloro-4-trifluoromethylbenzyl)-2,7-dimethyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid 

Relevant articles and documents

ARYLALKANOIC ACID DERIVATIVE

A compound represented by the formula (I): wherein Ar is an optionally substituted aromatic ring; Xa, Xc, Ya, Yc, Z1 and Z2 are each a bond, O, S, -CO-, -CS-, - CR3 (OR4) -, -NR5-, -SO-, -SO2-, -CONR6- or -NR6CO- (wherein R3, R4, R5 and R6 are as defined in the specification); Xb and Yb are each a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R1 is an optionally substituted hydrocarbon group; ring A is an optionally further substituted aromatic ring, provided that the ring should not be benzimidazole; n is an integer of 1 to 8; ring B is an optionally further substituted aromatic ring, provided that the ring should not be oxazole; W is a divalent saturated hydrocarbon group having 1 to 20 carbon atoms; and R2 is -OR8 or -NR9R10 (wherein R8, R9 and R10 are as defined in the specification) or a salt thereof, is useful as an agent for the prophylaxis or treatment of diabetes and the like.

ARYLALKANOIC ACID DERIVATIVE

A compound represented by the general formula (I): [wherein Ar represents an optionally substituted aromatic ring; Xa, Xc, Ya, Yc, Z1, and Z2 each represents a bond, O, S, -CO-, -CS-, -CR3(OR4)-, -NR5-, -SO-, -SO2-, -CONR6-, or -NR6CO- (R3, R4, R5, and R6 are as defined in the description); Xb and Yb each represents a bond or a C1-20 divalent hydrocarbon group; R1 represents an optionally substituted hydrocarbon group; ring A represents an aromatic ring (other than benzimidazole) which may be further substituted; n is an integer of 1-8; ring B represents an aromatic ring (other than oxazole) which may be further substituted; W represents a C1-20 divalent saturated hydrocarbon group; and R2 represents -OR8 or -NR9R10 (R8, R9, and R10 are as defined in the description)] or a salt of the compound. It is useful as a preventive/therapeutic agent for diabetes, etc.

BENZIMIDAZOLE DERIVATIVES

The present invention provides novel benzimidazole derivatives of the following formula (I) and salts thereof: wherein R1 represents a lower alkyl group or a lower alkyloxy-lower alkyl group: R2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, an aryl group, and such; R3 represents a lower alkyl group, a lower alkenyl group, an aryl group, a lower alkylaryl group, an aryl-lower alkenyl group, a halothienyl group, a lower alkylamino group, or an aryl-lower alkylamino group; A represents a benzene ring, a naphthalene ring, or a pyridine ring; and X represents a halogen atom. The derivatives and their salts have blood sugar level-depressing activity or PDE5-inhibiting activity, and are useful as pharmaceutical preparations.