74483-47-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-methylbenzotrifluoride is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex molecular structures, enhancing the development of new drugs.
Used in Agrochemical Industry:
3-Chloro-4-methylbenzotrifluoride is used as an intermediate in the synthesis of agrochemicals, playing a role in the creation of compounds that can help protect crops and enhance agricultural productivity.
Used in Consumer Product Manufacturing:
3-Chloro-4-methylbenzotrifluoride is used as a solvent in the manufacturing of various consumer products, contributing to the production process and the final quality of the products.

Upstream product

• 56-23-5 tetrachloromethane 
• 95-49-8 2-methylchlorobenzene 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 
• 83846-48-4 3-chloro-4-methyliodobenzene 
• 1448038-19-4 C₁₃H₂₀ClN₃ 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 279252-26-5 1-(bromomethyl)-2-chloro-4-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

Trifluoromethylation of 1-aryl-3,3-diisopropyltriazenes

A new method for the trifluoromethylation of functionalized aromatic diisopropyltriazenes is described. In a facile two-step, one-pot synthesis, various functionalized trifluoromethyl-substituted arenes are accessible in mostly good yields by using methyl iodide as iodination agent and the trifluoromethylation system (trifluoromethyl)trimethylsilane/potassium fluoride/copper iodide. This concept could be expanded to perfluoroethylation as well as ethoxycarbonyldifluoromethylation reactions. Copyright

Trifluoromethylated Vinylic and Aromatic Compounds from α-(Trifluoromethyl)allyl Alcohols

α-(Trifluoromethyl)allyl alcohols, easily available from α,β-unsaturated carbonyl compounds, are readily converted into γ-(trifluoromethyl)allyl thioethers, benzyl ethers, trifluoroacetates, and azides. A phenyl substituent at the γ-position to the hydroxyl function enhances their reactivity and the ease of SN2′ or SN1′ substitutions, whereas a phenyl ring at the α-position allows the BF3-mediated synthesis of (trifluoromethyl)indenes. 4-Alkyl-4-methoxy-1-(trifluoromethyl)cyclohexa-2,5- dienols, readily available from 4-alkylphenols, are easily converted to 4-alkyl(trifluoromethyl)benzenes bearing a nucleophilic substituent (MeO, Cl) either on the ring or the benzylic position.

IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF

Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy inhibitory action.

BENZIMIDAZOLE DERIVATIVES

The present invention provides novel benzimidazole derivatives of the following formula (I) and salts thereof: wherein R1 represents a lower alkyl group or a lower alkyloxy-lower alkyl group: R2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, an aryl group, and such; R3 represents a lower alkyl group, a lower alkenyl group, an aryl group, a lower alkylaryl group, an aryl-lower alkenyl group, a halothienyl group, a lower alkylamino group, or an aryl-lower alkylamino group; A represents a benzene ring, a naphthalene ring, or a pyridine ring; and X represents a halogen atom. The derivatives and their salts have blood sugar level-depressing activity or PDE5-inhibiting activity, and are useful as pharmaceutical preparations.

A New Method for the Trifluoromethylation of Aromatics

A new method is described for introducing a CF3-group, by a single-step synthesis, into aromatic compounds.This trifluoromethylation is done by means of a mixture consisting of HF/CCl4 and the aromatic compounds.The reaction is thought to be of a Friedel-Crafts type and limited to aromatics which are not substituted by electron withdrawing groups.